Product Name: HIRA Antibody
Species Reactivity: Human
Tested Applications: WB
Applications: For WB starting dilution is: 1:1000
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 112 kDa
Immunogen: This HIRA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-61 amino acids from the N-terminal region of human HIRA.
Host Species: Rabbit
Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
Physical State: Liquid
CAS NO.: 1796565-52-0
Product: Conduritol B epoxide
Buffer: Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration: 0.5 mg/ml
Storage Conditions: Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Protein HIRA, TUP1-like enhancer of split protein 1, HIRA, DGCR1, HIR, TUPLE1
Accession NO.: P54198
Protein Ino: 88984228
Official Symbol: HIRA
Geneid: 7290
Background: This gene encodes a histone chaperone that preferentiallyplaces the variant histone H3.3 in nucleosomes. Orthologs of thisgene in yeast, flies, and plants are necessary for the formation oftranscriptionally silent heterochomatin. This gene plays animportant role in the formation of the senescence-associatedheterochromatin foci. These foci likely mediate the irreversiblecell cycle changes that occur in senescent cells. It is consideredthe primary candidate gene in some haploinsufficiency syndromessuch as DiGeorge syndrome, and insufficient production of the genemay disrupt normal embryonic development.
PubMed ID:http://aac.asm.org/content/22/4/689.abstract
