Product Name: Hax1b Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB
Applications: Hax1b antibody can be used for detection of Hax1b by Western blot at 1 – 2 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: Hax1b antibody was raised against a 10 amino acid synthetic peptide near the amino terminus of human Hax1b.The immunogen is located within the first 50 amino acids of Hax1b.
Host Species: Rabbit
Purification: Hax1b Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 1026016-83-0
Product: Pipequaline
Buffer: Hax1b Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: Hax1b antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Hax1b Antibody: SCN3, HS1BP1, HCLSBP1, HCLS1-associated protein X-1, HS1-associating protein X-1, HAX-1
Accession NO.: NP_001018238
Protein Ino: 66363694
Official Symbol: HAX1
Geneid: 10456
Background: Hax1b Antibody: The HS-1 associated protein X-1 (Hax1) was initially identified in a yeast two-hybrid assay on the basis of its ability to bind to the hemapoietic cell-specific protein 1 (HS-1). Hax1 possesses anti-apoptotic activity and is structurally related to Bcl-2 family members, including the presence of BH1- and BH2-like domains. It has recently been shown to interact with HIV viral protein R (Vpr), a protein required for viral pathogenesis of HIV and linked to T-cell apoptosis through activation of caspases 3 and 9. Other studies indicate that Hax1-mediated processing of HtrA2 (also known as Omi) by the mitochondrial protease PARL allows survival of lymphocytes and neurons when cytokines are limiting.
PubMed ID:http://aac.asm.org/content/21/2/336.abstract
