Product Name: Bim Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, IHC-P, WB
Applications: Bim antibody can be used for detection of Bim by Western blot at 1 μg/mL. A 23 kDa band can be detected. Antibody can also be used for immunohistochemistry starting at 20 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 23 kDa
Immunogen: Bim antibody was raised against a 20 amino acid peptide corresponding to amino acids near the amino terminus of human Bim.The immunogen is located within the first 50 amino acids of Bim.
Host Species: Rabbit
Purification: Bim Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 2971-90-6
Product: Clopidol
Buffer: Bim Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: Bim antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Bim Antibody: BAM, BIM, BOD, Bcl-2-like protein 11, Bcl2-interacting mediator of cell death, Bcl2-L-11
Accession NO.: O43521
Protein Ino: 18202042
Official Symbol: BCL2L11
Geneid: 10018
Background: Bim Antibody: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bim or BOD in human, mouse and rat. Bim/BOD interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Bim/BOD induces apoptosis. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines.
PubMed ID:http://aac.asm.org/content/42/2/419.abstract
