Product Name: Beta III Tubulin Antibody [AA10]
Species Reactivity: Mammal
Tested Applications: IHC, WB
Applications:
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 55
Immunogen: Synthetic peptide corresponding to beta III tubulin.
Host Species: Mouse
Purification: Protein G purified
Physical State: Liquid
CAS NO.: 18444-66-1
Product: Cucurbitacin E
Buffer: 100 uL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA and 50% glycerol.
Concentration:
Storage Conditions: Beta III Tubulin antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.
Clonality: Monoclonal
Conjugate: Unconjugated
Alternate Names: Neuron-specific class III beta-tubulin,
Accession NO.: Q4QRB4
Protein Ino: 81918226
Official Symbol: Tubb3
Geneid: 246118
Background: Tubulin is the major constituent of microtubules, existing as a heterodimer of the alpha and beta subunits. The beta III isoform of tubulin is found almost exclusively in neuronal processes of adult tissues and is therefore an excellent marker for neurons. Neuron specific, posttranslational modifications within the C-terminal domain of beta III tubulin have been shown to be developmentally regulated suggesting that they may serve to modulate the interaction of tubulin with microtubule associated proteins (Lee et al., 1990). Additionally, beta III tubulin has been found to be highly expressed in cancer cells such as small cell lung cancer, large cell neuroendocrine carcinoma and adenocarcinomas and is correlated with an increasing histological degree of malignancy (Katsetos et al., 2003)
PubMed ID:http://aac.asm.org/content/42/1/184.abstract
