Product Name: Bcl-B Antibody
Species Reactivity: Human
Tested Applications: ELISA, ICC, WB
Applications: Bcl-B antibody can be used for the detection of Bcl-B by Western blot at 1 – 2 μg/mL. Despite its predicted molecular weight, Bcl-B is often at higher molecular weights, presumably due to post-translational modifications. Antibody can also be used for immunocytochemistry starting at 10 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: Predicted: 22 kDa Observed: 26 kDa
Immunogen: Bcl-B antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human Bcl-B.The immunogen is located within amino acids 90 – 140 of Bcl-B.
Host Species: Rabbit
Purification: Bcl-B Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 4696-76-8
Product: Bekanamycin
Buffer: Bcl-B Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: Bcl-B antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Bcl-B Antibody: Boo, Diva, BCL-B, BCLB, Bcl-2-like protein 10, Anti-apoptotic protein NrH, Bcl2-L-10
Accession NO.: NP_065129
Protein Ino: 9966783
Official Symbol: BCL2L10
Geneid: 10017
Background: Bcl-B Antibody: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-B is a recently discovered anti-apoptotic member of the Bcl-2. Unlike the mouse homolog (also known as Diva/Boo) which is predominantly expressed in ovary and testis, the human Bcl-B protein is widely expressed. Also, the human Bcl-B functions by binding to and suppressing the apoptotic activity of Bax, whereas the mouse homolog binds Bak and also interacts with the apoptosis protein Apaf-1.
PubMed ID:http://aac.asm.org/content/53/11/4778.abstract
