Product Name: B3GALT5 Antibody
Species Reactivity: Human
Tested Applications: WB
Applications: For WB starting dilution is: 1:1000For FACS starting dilution is: 1:10~50
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 36 kDa
Immunogen: This B3GALT5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 57-84 amino acids from the N-terminal region of human B3GALT5.
Host Species: Rabbit
Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
Physical State: Liquid
CAS NO.: 64-65-3
Product: Bemegride
Buffer: Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration: 0.5 mg/ml
Storage Conditions: Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Beta-1,3-galactosyltransferase 5, Beta-1,3-GalTase 5, Beta3Gal-T5, Beta3GalT5, b3Gal-T5, 241-, Beta-3-Gx-T5, UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5, UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5, B3GALT5
Accession NO.: Q9Y2C3
Protein Ino: 13123995
Official Symbol: B3GALT5
Geneid: 10317
Background: This gene is a member of thebeta-1,3-galactosyltransferase (beta3GalT) gene family. This familyencodes type II membrane-bound glycoproteins with diverse enzymaticfunctions using different donor substrates (UDP-galactose andUDP-N-acetylglucosamine) and different acceptor sugars(N-acetylglucosamine, galactose, N-acetylgalactosamine). Thebeta3GalT genes are distantly related to the Drosophila Brainiacgene and have the protein coding sequence contained in a singleexon. The beta3GalT proteins also contain conserved sequences notfound in the beta4GalT or alpha3GalT proteins. The carbohydratechains synthesized by these enzymes are designated as type 1,whereas beta4GalT enzymes synthesize type 2 carbohydrate chains.The ratio of type 1:type 2 chains changes during embryogenesis. Bysequence similarity, the beta3GalT genes fall into at least twogroups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3,beta3GalT5). This gene encodes the most probable candidate forsynthesis of the type 1 Lewis antigens which are frequently foundto be elevated in gastrointestinal and pancreatic cancers. Theencoded protein is inactive with N-linked glycoproteins andfunctions in mucin glycosylation. Five transcript variants havebeen described which differ in the 5 UTR. All transcript variantsencode an identical protein.
PubMed ID:http://aac.asm.org/content/53/9/4022.abstract
