Product Name: ATRX Antibody [39f]
Species Reactivity: Human
Tested Applications: Flow, IF, IHC-P, WB
Applications: IHC (FFPE): 0.5-1 ug/ml for 30 min at RTWB: 0.5-1 ug/mlFlow Cytometry: 0.5-1ug/10^6 cells in 0.1mlIF: 1-2 ug/mlThe concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the ATRX antibody to be titered up or down for optimal performance.
User Note: Optimal dilutions for each application to be determined by the researcher
Predicted Molecular Weight:
Immunogen: Recombinant human ATRX protein was used as the immunogen for this ATRX antibody.
Host Species: Mouse
Purification: Protein G affinity chromatography
Physical State: Liquid
CAS NO.: 3317-67-7
Product: Cobalt phthalocyanine
Buffer: PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration: 0.2 mg/mL
Storage Conditions: Aliquot and Store at -20C. Avoid freez-thaw cycles.
Clonality: Monoclonal
Conjugate: Unconjugated
Alternate Names: ATRX, alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae), RP5-875J14.1, ATR2, MGC2094, MRXS3, RAD54, RAD54L, SHS, XH2, XNP, ZNF-HX , DNA dependent ATPase and helicase, OTTHUMP00000062079, RAD54 (Saccharomyces cerevisiae)
Accession NO.:
Protein Ino:
Official Symbol: ATRX
Geneid: 546
Background: ATRX is a member of the Snf2 family of helicase/ATPases, which contribute to the remodeling of the nucelosome structure in an ATP-dependent manner, and facilitate the initiation of transcription and replication. Structurally, it contains a PHD zinc finger motif. ATRX is regulated throughout the cell cycle where it is differentially distributed within the nucleus. During interphase, it predominately associates with the nuclear matrix, while during mitosis, ATRX localizes with condensed chromatin. At the onset of M phase, phosphorylation rapidly induces this redistribution of ATRX to the short arms of human acrocentric chromosomes, where it then specifically complexes with heterochromatin protein 1 alpha to mediate chromosomal segregation. Mutations in the gene correlate with a high incidence of severe X-linked form of syndromal mental retardation associated with alpha thalassemia or ATRX syndrome
PubMed ID:http://aac.asm.org/content/53/8/3205.abstract
