Product Name: ATM (phospho Ser1981) Antibody
Species Reactivity: Human, Mouse
Tested Applications: IHC, WB
Applications: Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
User Note:
Predicted Molecular Weight: 350 kDa
Immunogen: ATM (Phospho-Ser1981) antibody was raised against a peptide sequence around phosphorylation site of serine 1981 (E-G-S (p) -Q-S) derived from Human ATM.
Host Species: Rabbit
Purification: Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Physical State: Liquid
CAS NO.: 14937-32-7
Product: 1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose
Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration: 1 mg/mL
Storage Conditions: Store antibody at -20˚C for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: AT1, ATA, ATC, ATD, ATE, ATDC, TEL1, TELO1, APRF, Ataxia telangiectasia mutated homolog, Ataxia telangiectasia mutated, kinase ATM
Accession NO.: NP_000042.3
Protein Ino: 71902540
Official Symbol: ATM
Geneid: 472
Background: ATM encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. Two transcript variants encoding different isoforms have been found for this gene.
PubMed ID:http://aac.asm.org/content/53/7/3166.abstract
