Product Name: APO-E Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, IF, IHC-P, WB
Applications: APO-E antibody can be used for detection of APO-E by Western blot at 1 – 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: Predicted: 35 kDa Observed: 34 kDa
Immunogen: APO-E antibody was raised against a 19 amino acid peptide near the carboxy terminus of human APO-E.The immunogen is located within amino acids 220 – 270 of APO-E.
Host Species: Rabbit
Purification: APO-E Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 107091-89-4
Product: Thiazole Orange
Buffer: APO-E Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: APO-E antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: APO-E Antibody: AD2, LPG, LDLCQ5, Apolipoprotein E, Apo-E
Accession NO.: NP_000032
Protein Ino: 4557325
Official Symbol: APOE
Geneid: 348
Background: APO-E Antibody: Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E (APO-E), a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Defects in APO-E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
PubMed ID:http://aac.asm.org/content/53/2/839.abstract
