Product Name: APC13 Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, IF, WB
Applications: APC13 antibody can be used for detection of APC13 by Western blot at 1 μg/mL. For immunofluorescence start at 20 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: Predicted: 15 kDa Observed: 14 kDa
Immunogen: APC13 antibody was raised against a 17 amino acid synthetic peptide near the center of human APC13.The immunogen is located within the last 50 amino acids of APC13.
Host Species: Rabbit
Purification: APC13 Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 103656-40-2
Product: Calcitriol Impurities D
Buffer: APC13 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: APC13 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: APC13 Antibody: SWM1, APC13, Anaphase-promoting complex subunit 13, Cyclosome subunit 13
Accession NO.: NP_056206
Protein Ino: 32698710
Official Symbol: ANAPC13
Geneid: 25847
Background: APC13 Antibody: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC13 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. APC13 promotes the stable association of APC3/Cdc27 and APC6/Cdc16 with the APC/C.
PubMed ID:http://aac.asm.org/content/53/2/505.abstract
