Product Name :
Rabbit anti-FKBP12 Polyclonal Antibody(Center)
Synonym :
Peptidyl-prolyl cis-trans isomerase FKBP1A; PPIase FKBP1A; 12 kDa FK506-binding protein; 12 kDa FKBP; FKBP-12; Calstabin-1; FK506-binding protein 1A; FKBP-1A; Immunophilin FKBP12; Rotamase; FKBP1A; FKBP1; FKBP12
Host :
Rabbit
Species Reactivity:
Human
Specificity :
This FKBP12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 43-74 amino acids from the Central region of human FKBP12.
Predicted Reactivity:
Bovine, Mouse, Rabbit, Rat
Applications :
WB~~1:1000IHC-P~~1:10~50
Immunogen:
Concentration :
Purification :
Clonality:
Polyclonal Antibody
Storage Temp.:
Maintain refrigerated at 2-8 ° C for up to 2 weeksFor long term storage store at -20 ° C in small aliquots to prevent free that cycles
Research areas :
Immunology
Background :
Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
UniProt :
P62942
Additional information:
Product Details FAQ Citations(0) Video Pictures Documents |Overview |Description Purified Rabbit Polyclonal Antibody (Pab) |Synonym Peptidyl-prolyl cis-trans isomerase FKBP1A; PPIase FKBP1A; 12 kDa FK506-binding protein; 12 kDa FKBP; FKBP-12; Calstabin-1; FK506-binding protein 1A; FKBP-1A; Immunophilin FKBP12; Rotamase; FKBP1A; FKBP1; FKBP12 |Host Rabbit |Specificity This FKBP12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 43-74 amino acids from the Central region of human FKBP12. |Species Reactivity Human |Predicted Reactivity Bovine, Mouse, Rabbit, Rat |Applications WB~~1:1000IHC-P~~1:10~50 |Properties |Clonality Polyclonal Antibody |Isotype Rabbit Ig |Storage Temp. Maintain refrigerated at 2-8 ° C for up to 2 weeksFor long term storage store at -20 ° C in small aliquots to prevent free that cycles |Storage Buffer Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |Research areas Immunology |Target |Background Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. |Cellular localization Cytoplasm. |UniProt P62942 |References |References Gerard,M., J. Neurochem. 106 (1), 121-133 (2008)Shor,B., Cancer Res. 68 (8), 2934-2943 (2008)Jayaraman,T.,J. Biol. Chem. 267 (14), 9474-9477 (1992) |Tips:This product is for research use only. Not for use in diagnostic prodcedures.
Rabbit anti-FKBP12 Polyclonal Antibody(Center)
Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.Related websites: https://www.medchemexpress.com/antibodies.html
1044758-60-2 medchemexpress 160162-42-5 References PMID:29489158 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com
