Product Name :
Ac2-12 TFA
Description:
Ac2-12 TFA, an annexin/lipocortin 1 (LC1)-mimetic peptide, inhibit neutrophil extravasation. Ac2-12 TFA has antimigratory action and inhibits recruitment of neutrophils in experimental inflammation models.
CAS:
Molecular Weight:
1465.59
Formula:
C65H95F3N14O19S
Chemical Name:
(2S, 5S, 8S, 11S, 14S, 17S, 20S)-2-((1H-indol-3-yl)methyl)-8-(3-amino-3-oxopropyl)-11-(4-aminobutyl)-17-benzyl-20-((2S, 5S, 8S, 11S)-2-(hydroxymethyl)-5-isopropyl-11-methyl-8-(2-(methylthio)ethyl)-4, 7, 10, 13-tetraoxo-3, 6, 9, 12-tetraazatetradecanamido)-14-isobutyl-5-methyl-4, 7, 10, 13, 16, 19-hexaoxo-3, 6, 9, 12, 15, 18-hexaazatricosanedioic acid–2, 2, 2-trifluoroacetic acid (1/1)
Smiles :
CC(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1C=CC=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC2=CC=CC=C12)C(O)=O.OC(=O)C(F)(F)F
InChiKey:
QUEWKNBREKFLND-HYQUBYKOSA-N
InChi :
InChI=1S/C63H94N14O17S.C2HF3O2/c1-33(2)28-46(59(89)70-42(20-14-15-26-64)56(86)71-43(21-23-50(65)80)55(85)68-36(6)54(84)75-48(63(93)94)30-39-31-66-41-19-13-12-18-40(39)41)73-60(90)47(29-38-16-10-9-11-17-38)74-57(87)44(22-24-51(81)82)72-61(91)49(32-78)76-62(92)52(34(3)4)77-58(88)45(25-27-95-8)69-53(83)35(5)67-37(7)79;3-2(4,5)1(6)7/h9-13,16-19,31,33-36,42-49,52,66,78H,14-15,20-30,32,64H2,1-8H3,(H2,65,80)(H,67,79)(H,68,85)(H,69,83)(H,70,89)(H,71,86)(H,72,91)(H,73,90)(H,74,87)(H,75,84)(H,76,92)(H,77,88)(H,81,82)(H,93,94);(H,6,7)/t35-,36-,42-,43-,44-,45-,46-,47-,48-,49-,52-;/m0.Zanubrutinib medchemexpress /s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Ac2-12 TFA, an annexin/lipocortin 1 (LC1)-mimetic peptide, inhibit neutrophil extravasation. Ac2-12 TFA has antimigratory action and inhibits recruitment of neutrophils in experimental inflammation models.Protein A/G Agarose medchemexpress |Product information|Molecular Weight: 1465.PMID:33325311 59|Formula: C65H95F3N14O19S|Chemical Name: (2S, 5S, 8S, 11S, 14S, 17S, 20S)-2-((1H-indol-3-yl)methyl)-8-(3-amino-3-oxopropyl)-11-(4-aminobutyl)-17-benzyl-20-((2S, 5S, 8S, 11S)-2-(hydroxymethyl)-5-isopropyl-11-methyl-8-(2-(methylthio)ethyl)-4, 7, 10, 13-tetraoxo-3, 6, 9, 12-tetraazatetradecanamido)-14-isobutyl-5-methyl-4, 7, 10, 13, 16, 19-hexaoxo-3, 6, 9, 12, 15, 18-hexaazatricosanedioic acid–2, 2, 2-trifluoroacetic acid (1/1)|Smiles: CC(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1C=CC=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC2=CC=CC=C12)C(O)=O.OC(=O)C(F)(F)F|InChiKey: QUEWKNBREKFLND-HYQUBYKOSA-N|InChi: InChI=1S/C63H94N14O17S.C2HF3O2/c1-33(2)28-46(59(89)70-42(20-14-15-26-64)56(86)71-43(21-23-50(65)80)55(85)68-36(6)54(84)75-48(63(93)94)30-39-31-66-41-19-13-12-18-40(39)41)73-60(90)47(29-38-16-10-9-11-17-38)74-57(87)44(22-24-51(81)82)72-61(91)49(32-78)76-62(92)52(34(3)4)77-58(88)45(25-27-95-8)69-53(83)35(5)67-37(7)79;3-2(4,5)1(6)7/h9-13,16-19,31,33-36,42-49,52,66,78H,14-15,20-30,32,64H2,1-8H3,(H2,65,80)(H,67,79)(H,68,85)(H,69,83)(H,70,89)(H,71,86)(H,72,91)(H,73,90)(H,74,87)(H,75,84)(H,76,92)(H,77,88)(H,81,82)(H,93,94);(H,6,7)/t35-,36-,42-,43-,44-,45-,46-,47-,48-,49-,52-;/m0./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Ac2-12 TFA (i.v.; 6.7 mg/kg, ≈70 nmol per mouse), was found to mimic the actions of lipocortin 1 (LC1) and Ac2-26 in male Swiss Albino mice (10-15 g). Ac2-12 TFA (100 μg) significantly reduces polymorphonuclear leukocyte (PMN) influx in wild-type C57BL/6 mice and is no longer active in FPR KO mice.|Products are for research use only. Not for human use.|
