Product Name :
Dihydroisotanshinone I
Description:
Dihydroisotanshinone I is a bioactive compound present in a widely used traditional Chinese medicine named danshen.
CAS:
20958-18-3
Molecular Weight:
278.30
Formula:
C18H14O3
Chemical Name:
4, 8-dimethyl-7H, 8H, 9H, 11H-phenanthro[3, 2-b]furan-7, 11-dione
Smiles :
CC1=CC=CC2=C1C=CC1=C2C(=O)C2OCC(C)C=2C1=O
InChiKey:
KXNYCALHDXGJSF-UHFFFAOYSA-N
InChi :
InChI=1S/C18H14O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)18-14(16(13)19)10(2)8-21-18/h3-7,10H,8H2,1-2H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Dihydroisotanshinone I is a bioactive compound present in a widely used traditional Chinese medicine named danshen.|Product information|CAS Number: 20958-18-3|Molecular Weight: 278.30|Formula: C18H14O3|Chemical Name: 4, 8-dimethyl-7H, 8H, 9H, 11H-phenanthro[3, 2-b]furan-7, 11-dione|Smiles: CC1=CC=CC2=C1C=CC1=C2C(=O)C2OCC(C)C=2C1=O|InChiKey: KXNYCALHDXGJSF-UHFFFAOYSA-N|InChi: InChI=1S/C18H14O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)18-14(16(13)19)10(2)8-21-18/h3-7,10H,8H2,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 3.33 mg/mL (11.97 mM; ultrasonic and warming and heat to 40°C)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Dihydroisotanshinone I can inhibit the migration of both androgen-dependent and androgen-independent prostate cancer cells.{{Taletrectinib} medchemexpress|{Taletrectinib} ROS Kinase|{Taletrectinib} Purity & Documentation|{Taletrectinib} Purity|{Taletrectinib} manufacturer|{Taletrectinib} Epigenetics} Dihydroisotanshinone diminishes the ability of prostate cancer cells to recruit macrophages and reduces the secretion of chemokine (C-C motif) ligand 2 (CCL2) from both macrophages and prostate cancer cells in a dose-dependent manner. It inhibits the protein expression of p-STAT3 and decreases the translocation of STAT3 into nuclear chromatin.{{Carboxyl Magnetic Beads} medchemexpress|{Carboxyl Magnetic Beads} TGF-beta/Smad|{Carboxyl Magnetic Beads} Protocol|{Carboxyl Magnetic Beads} Description|{Carboxyl Magnetic Beads} supplier} It also suppresses the expression of tumor epithelial-mesenchymal transition genes, including RhoA and SNAI1.PMID:33205203 Pretreating the cells with dihydroisotanshinone I at concentrations ranging from 2.5 μM to 20 μM for 24 hours cause dose-dependent protection against hepatotoxicity induced by menadione. Adding dihydroisotanshinone I to freshly isolated hepatocytes at concentrations between 50 nM to 200 nM inhibit NADH-induced superoxide production dose-dependently.|References:|Wu CY, et al. Anti-cancer effect of danshen and dihydroisotanshinone I on prostate cancer: targeting the crosstalk between macrophages and cancer cells via inhibition of the STAT3/CCL2 signaling pathway. Oncotarget. 2017 Feb 1.Ip SP, et al. Dihydroisotanshinone I protects against menadione-induced toxicity in a primary culture of rat hepatocytes. Planta Med. 2002 Dec;68(12):1077-81.Products are for research use only. Not for human use.|
