Product Name :
Thalidomide-Propargyne-PEG3-COOH
Description:
Thalidomide-Propargyne-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
CAS:
Molecular Weight:
472.44
Formula:
C23H24N2O9
Chemical Name:
3-{2-[2-({3-[2-(2, 6-dioxopiperidin-3-yl)-1, 3-dioxo-2, 3-dihydro-1H-isoindol-5-yl]prop-2-yn-1-yl}oxy)ethoxy]ethoxy}propanoic acid
Smiles :
OC(=O)CCOCCOCCOCC#CC1=CC2=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)C2=O
InChiKey:
WWIBTSXCGDRYOX-UHFFFAOYSA-N
InChi :
InChI=1S/C23H24N2O9/c26-19-6-5-18(21(29)24-19)25-22(30)16-4-3-15(14-17(16)23(25)31)2-1-8-32-10-12-34-13-11-33-9-7-20(27)28/h3-4,14,18H,5-13H2,(H,27,28)(H,24,26,29)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Fluvoxamine} site|{Fluvoxamine} Serotonin Transporter|{Fluvoxamine} Protocol|{Fluvoxamine} Description|{Fluvoxamine} custom synthesis|{Fluvoxamine} Epigenetic Reader Domain}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Thalidomide-Propargyne-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.|Product information|Molecular Weight: 472.44|Formula: C23H24N2O9|Chemical Name: 3-{2-[2-({3-[2-(2, 6-dioxopiperidin-3-yl)-1, 3-dioxo-2, 3-dihydro-1H-isoindol-5-yl]prop-2-yn-1-yl}oxy)ethoxy]ethoxy}propanoic acid|Smiles: OC(=O)CCOCCOCCOCC#CC1=CC2=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)C2=O|InChiKey: WWIBTSXCGDRYOX-UHFFFAOYSA-N|InChi: InChI=1S/C23H24N2O9/c26-19-6-5-18(21(29)24-19)25-22(30)16-4-3-15(14-17(16)23(25)31)2-1-8-32-10-12-34-13-11-33-9-7-20(27)28/h3-4,14,18H,5-13H2,(H,27,28)(H,24,26,29)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Adenosine receptor antagonist 2} site|{Adenosine receptor antagonist 2} Antagonist|{Adenosine receptor antagonist 2} Activator|{Adenosine receptor antagonist 2} Technical Information|{Adenosine receptor antagonist 2} Data Sheet|{Adenosine receptor antagonist 2} custom synthesis} |Shelf Life: ≥12 months if stored properly.PMID:33345753 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-988.Products are for research use only. Not for human use.|
