Product Name :
MC-SN38
Description:
MC-SN38 is a drug-linker conjugate composed of a potent microtubule-disrupting agent SN38 and a non-cleavable MC linker to make antibody drug conjugate (ADC). SN-38, an active metabolite of the Topoisomerase I inhibitor Irinotecan, inhibits DNA synthesis and causes frequent DNA single-strand breaks.
CAS:
1473403-87-0
Molecular Weight:
585.60
Formula:
C32H31N3O8
Chemical Name:
(19S)-10,19-diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²,¹¹.0⁴,⁹.0¹⁵,²⁰]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoate
Smiles :
CC[C@]1(OC(=O)CCCCCN2C(=O)C=CC2=O)C2C=C3C4=NC5=CC=C(O)C=C5C(CC)=C4CN3C(=O)C=2COC1=O
InChiKey:
ACRMADURFCYBAU-YTTGMZPUSA-N
InChi :
InChI=1S/C32H31N3O8/c1-3-19-20-14-18(36)9-10-24(20)33-29-21(19)16-35-25(29)15-23-22(30(35)40)17-42-31(41)32(23,4-2)43-28(39)8-6-5-7-13-34-26(37)11-12-27(34)38/h9-12,14-15,36H,3-8,13,16-17H2,1-2H3/t32-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Lebrikizumab} web|{Lebrikizumab} Interleukin Related|{Lebrikizumab} Purity & Documentation|{Lebrikizumab} Formula|{Lebrikizumab} supplier|{Lebrikizumab} Epigenetic Reader Domain}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
MC-SN38 is a drug-linker conjugate composed of a potent microtubule-disrupting agent SN38 and a non-cleavable MC linker to make antibody drug conjugate (ADC). SN-38, an active metabolite of the Topoisomerase I inhibitor Irinotecan, inhibits DNA synthesis and causes frequent DNA single-strand breaks.|Product information|CAS Number: 1473403-87-0|Molecular Weight: 585.60|Formula: C32H31N3O8|Chemical Name: (19S)-10,19-diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²,¹¹.0⁴,⁹.0¹⁵,²⁰]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoate|Smiles: CC[C@]1(OC(=O)CCCCCN2C(=O)C=CC2=O)C2C=C3C4=NC5=CC=C(O)C=C5C(CC)=C4CN3C(=O)C=2COC1=O|InChiKey: ACRMADURFCYBAU-YTTGMZPUSA-N|InChi: InChI=1S/C32H31N3O8/c1-3-19-20-14-18(36)9-10-24(20)33-29-21(19)16-35-25(29)15-23-22(30(35)40)17-42-31(41)32(23,4-2)43-28(39)8-6-5-7-13-34-26(37)11-12-27(34)38/h9-12,14-15,36H,3-8,13,16-17H2,1-2H3/t32-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 140 mg/mL (239.{{Pioglitazone} MedChemExpress|{Pioglitazone} Cell Cycle/DNA Damage|{Pioglitazone} Purity & Documentation|{Pioglitazone} Description|{Pioglitazone} custom synthesis|{Pioglitazone} Epigenetics} 07 mM; Need ultrasonic).PMID:33305413 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
