Product Name :
TC-I 2014
Description:
TC-I 2014 (compound 5) is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonist, with IC50 values of 0.8 nM, 3.0 nM and 4.4 nM for canine, human and rat channels respectively. TC-I 2014 exhibits antiallodynic properties in pain models.
CAS:
1221349-53-6
Molecular Weight:
467.41
Formula:
C23H19F6N3O
Chemical Name:
3-[7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-1,3-benzodiazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene
Smiles :
FC(F)(F)C1=CC=CC=C1C1C=C2N=C(NC2=C(C=1)C(F)(F)F)C1CC2(CCCCC2)ON=1
InChiKey:
VSMFCZZEKTVDHM-UHFFFAOYSA-N
InChi :
InChI=1S/C23H19F6N3O/c24-22(25,26)15-7-3-2-6-14(15)13-10-16(23(27,28)29)19-17(11-13)30-20(31-19)18-12-21(33-32-18)8-4-1-5-9-21/h2-3,6-7,10-11H,1,4-5,8-9,12H2,(H,30,31)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
TC-I 2014 (compound 5) is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonist, with IC50 values of 0.8 nM, 3.0 nM and 4.4 nM for canine, human and rat channels respectively. TC-I 2014 exhibits antiallodynic properties in pain models.|Product information|CAS Number: 1221349-53-6|Molecular Weight: 467.41|Formula: C23H19F6N3O|Chemical Name: 3-[7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-1,3-benzodiazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene|Smiles: FC(F)(F)C1=CC=CC=C1C1C=C2N=C(NC2=C(C=1)C(F)(F)F)C1CC2(CCCCC2)ON=1|InChiKey: VSMFCZZEKTVDHM-UHFFFAOYSA-N|InChi: InChI=1S/C23H19F6N3O/c24-22(25,26)15-7-3-2-6-14(15)13-10-16(23(27,28)29)19-17(11-13)30-20(31-19)18-12-21(33-32-18)8-4-1-5-9-21/h2-3,6-7,10-11H,1,4-5,8-9,12H2,(H,30,31)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Fluorescein} MedChemExpress|{Fluorescein} {Fluorescent Dye}|{Fluorescein} Technical Information|{Fluorescein} Data Sheet|{Fluorescein} custom synthesis|{Fluorescein} Autophagy} |Shelf Life: ≥12 months if stored properly.{{Nusinersen} site|{Nusinersen} Cell Cycle/DNA Damage|{Nusinersen} Protocol|{Nusinersen} References|{Nusinersen} supplier|{Nusinersen} Cancer} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23290930 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|TC-I 2014 (compound 5) potently inhibits cold-induced TRPM8 currents in HEK293 cells stably expressing canine or human TRPM8, with IC50 values of 0.413 and 1 nM, respectively.|In Vivo:|TC-I 2014 (10 mg/kg, Orally once) completely prevents icilin-induced WDS.|Products are for research use only. Not for human use.|
