Product Name: AIMP2 Antibody
Species Reactivity: Human
Tested Applications: ELISA, IF, IHC-P, WB
Applications: AIMP2 antibody can be used for detection of AIMP2 by Western blot at 1 – 2 μg/ml.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: Predicted: 35 kDa Observed: 36 kDa
Immunogen: AIMP2 antibody was raised against a 16 amino acid peptide near the center of human AIMP2.The immunogen is located within amino acids 150 – 200 of AIMP2.
Host Species: Rabbit
Purification: AIMP2 antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 1446790-62-0
Product: RO9021
Buffer: AIMP2 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: AIMP2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: AIMP2 Antibody: P38, JTV1, JTV-1, PRO0992, Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, Multisynthase complex auxiliary component p38
Accession NO.: NP_006294
Protein Ino: 11125770
Official Symbol: AIMP2
Geneid: 7965
Background: AIMP2 was initially identified as a part of an aminoacyl-tRNA synthesase complex (1). It was later discovered to be a cofactor and substrate of Parkin, a Ring-type E3 ubiquitin ligase that is important for the survival of dopamine neurons in Parkinson’s disease; accumulation of AIMP2 in these cells lead to catecholaminergic cell death (2). AIMP2 can also bind to TRAF2, a key player in the TNF-alpha signaling pathway, causing the ubiquitination of TRAF2 by cIAP1, leading to TNF-alpha-dependent apoptosis (3). Finally, AIMP2 has been suggested to function as a tumor suppressor (4).
PubMed ID:http://aac.asm.org/content/52/7/2449.abstract
