Product Name :
PRMT1-2e, Protein Arginine Methyltransferase 1 (PRMT1) Inhibitor
Description:
PRMT1-2e is a potent, specific and cell permeable inhibitor of protein arginine methyltransferase 1 (PRMT1) with an IC50 ~1.5 μM. It has no activity against CARM1 and Set7/9 methyltransferases. It inhibits growth of MCF7a breast cancer cells (IC50 ~1.97 μM) and LNCaP prostate cancer cells (IC50 ~4.49 μM). It can attenuate androgen-induced gene expression in LNCaP cells.
CAS:
17328-16-4
Molecular Weight:
401.26
Formula:
C16H14Cl2N2O4S
Chemical Name:
N,N’-(sulfonylbis(4,1-phenylene))bis(2-chloroacetamide)
Smiles :
O=S(=O)(C1C=CC(=CC=1)NC(=O)CCl)C1C=CC(=CC=1)NC(=O)CCl
InChiKey:
SHRCVZJKZJGIHQ-UHFFFAOYSA-N
InChi :
InChI=1S/C16H14Cl2N2O4S/c17-9-15(21)19-11-1-5-13(6-2-11)25(23,24)14-7-3-12(4-8-14)20-16(22)10-18/h1-8H,9-10H2,(H,19,21)(H,20,22)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
PRMT1-2e is a potent, specific and cell permeable inhibitor of protein arginine methyltransferase 1 (PRMT1) with an IC50 ~1.5 μM. It has no activity against CARM1 and Set7/9 methyltransferases. It inhibits growth of MCF7a breast cancer cells (IC50 ~1.97 μM) and LNCaP prostate cancer cells (IC50 ~4.{{Osthole} site|{Osthole} GPCR/G Protein|{Osthole} Biological Activity|{Osthole} Description|{Osthole} custom synthesis|{Osthole} Epigenetics} 49 μM).{{Purmorphamine} site|{Purmorphamine} Autophagy|{Purmorphamine} Immunology/Inflammation|{Purmorphamine} Technical Information|{Purmorphamine} Purity|{Purmorphamine} manufacturer} It can attenuate androgen-induced gene expression in LNCaP cells.PMID:25105126 |Product information|CAS Number: 17328-16-4|Molecular Weight: 401.26|Formula: C16H14Cl2N2O4S|Chemical Name: N,N’-(sulfonylbis(4,1-phenylene))bis(2-chloroacetamide)|Smiles: O=S(=O)(C1C=CC(=CC=1)NC(=O)CCl)C1C=CC(=CC=1)NC(=O)CCl|InChiKey: SHRCVZJKZJGIHQ-UHFFFAOYSA-N|InChi: InChI=1S/C16H14Cl2N2O4S/c17-9-15(21)19-11-1-5-13(6-2-11)25(23,24)14-7-3-12(4-8-14)20-16(22)10-18/h1-8H,9-10H2,(H,19,21)(H,20,22)|Technical Data|Appearance: Solid Power.|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO up to 50 mM|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|PRMT1-2e was used at 10 µM in vitro.|References:|Bissinger EM, et al. Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1. (2011) Bioorg Med Chem. 19(12):3717-31.Products are for research use only. Not for human use.|Documents||
