Product Name :
AM-6494
Description:
AM-6494 is a potent and orally active BACE1 (efficacious β-site amyloid precursor protein cleaving enzyme 1) inhibitor (IC50=0.4 nM) with in vivo selectivity over BACE2 (IC50=18.6 nM).
CAS:
1874232-80-0
Molecular Weight:
473.50
Formula:
C22H21F2N5O3S
Chemical Name:
N-{3-[(1S,5S,6S)-3-amino-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl}-5-(prop-2-yn-1-yloxy)pyrazine-2-carboxamide
Smiles :
C[C@@]1(N=C(N)S[C@@]2(COC)C[C@@H]12)C1=CC(=CC(F)=C1F)NC(=O)C1=CN=C(C=N1)OCC#C
InChiKey:
IPUJINDWAGRAHN-KNXBSLHKSA-N
InChi :
InChI=1S/C22H21F2N5O3S/c1-4-5-32-17-10-26-15(9-27-17)19(30)28-12-6-13(18(24)14(23)7-12)21(2)16-8-22(16,11-31-3)33-20(25)29-21/h1,6-7,9-10,16H,5,8,11H2,2-3H3,(H2,25,29)(H,28,30)/t16-,21+,22+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
AM-6494 is a potent and orally active BACE1 (efficacious β-site amyloid precursor protein cleaving enzyme 1) inhibitor (IC50=0.4 nM) with in vivo selectivity over BACE2 (IC50=18.6 nM).|Product information|CAS Number: 1874232-80-0|Molecular Weight: 473.50|Formula: C22H21F2N5O3S|Chemical Name: N-{3-[(1S,5S,6S)-3-amino-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.{{D-Pantothenic acid} web|{D-Pantothenic acid} Metabolic Enzyme/Protease|{D-Pantothenic acid} Biological Activity|{D-Pantothenic acid} In Vivo|{D-Pantothenic acid} supplier|{D-Pantothenic acid} Epigenetic Reader Domain} 1.{{Lovastatin} site|{Lovastatin} Autophagy|{Lovastatin} Technical Information|{Lovastatin} Description|{Lovastatin} custom synthesis|{Lovastatin} Epigenetic Reader Domain} 0]hept-3-en-5-yl]-4,5-difluorophenyl}-5-(prop-2-yn-1-yloxy)pyrazine-2-carboxamide|Smiles: C[C@@]1(N=C(N)S[C@@]2(COC)C[C@@H]12)C1=CC(=CC(F)=C1F)NC(=O)C1=CN=C(C=N1)OCC#C|InChiKey: IPUJINDWAGRAHN-KNXBSLHKSA-N|InChi: InChI=1S/C22H21F2N5O3S/c1-4-5-32-17-10-26-15(9-27-17)19(30)28-12-6-13(18(24)14(23)7-12)21(2)16-8-22(16,11-31-3)33-20(25)29-21/h1,6-7,9-10,16H,5,8,11H2,2-3H3,(H2,25,29)(H,28,30)/t16-,21+,22+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:23453497 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
