Product Name :
LXW7
Description:
LXW7, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor. LXW7 has a high binding affinity to αvβ3 integrin with an IC50 of 0.68 μM. LXW7 increases phosphorylation of VEGFR-2 and activation of ERK1/2. Anti-inflammatory effect.
CAS:
1313004-77-1
Molecular Weight:
820.89
Formula:
C29H48N12O12S2
Chemical Name:
2-[(4S,7R,10R,13S,19S,25S)-25-amino-4-carbamoyl-13-(carboxymethyl)-19-{3-[(diaminomethylidene)amino]propyl}-6,9,12,15,18,21,24-heptaoxo-7-(propan-2-yl)-1,2-dithia-5,8,11,14,17,20,23-heptaazacyclohexacosan-10-yl]acetic acid
Smiles :
CC(C)[C@H]1NC(=O)[C@@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(=O)[C@H](N)CSSC[C@@H](NC1=O)C(N)=O
InChiKey:
UUJIUMRQOUEUEJ-NBJCVSNRSA-N
InChi :
InChI=1S/C29H48N12O12S2/c1-12(2)22-28(53)40-17(23(31)48)11-55-54-10-13(30)24(49)35-8-18(42)37-14(4-3-5-34-29(32)33)25(50)36-9-19(43)38-15(6-20(44)45)26(51)39-16(7-21(46)47)27(52)41-22/h12-17,22H,3-11,30H2,1-2H3,(H2,31,48)(H,35,49)(H,36,50)(H,37,42)(H,38,43)(H,39,51)(H,40,53)(H,41,52)(H,44,45)(H,46,47)(H4,32,33,34)/t13-,14+,15+,16-,17-,22-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
LXW7, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor. LXW7 has a high binding affinity to αvβ3 integrin with an IC50 of 0.68 μM. LXW7 increases phosphorylation of VEGFR-2 and activation of ERK1/2. Anti-inflammatory effect.|Product information|CAS Number: 1313004-77-1|Molecular Weight: 820.89|Formula: C29H48N12O12S2|Chemical Name: 2-[(4S,7R,10R,13S,19S,25S)-25-amino-4-carbamoyl-13-(carboxymethyl)-19-{3-[(diaminomethylidene)amino]propyl}-6,9,12,15,18,21,24-heptaoxo-7-(propan-2-yl)-1,2-dithia-5,8,11,14,17,20,23-heptaazacyclohexacosan-10-yl]acetic acid|Smiles: CC(C)[C@H]1NC(=O)[C@@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(=O)[C@H](N)CSSC[C@@H](NC1=O)C(N)=O|InChiKey: UUJIUMRQOUEUEJ-NBJCVSNRSA-N|InChi: InChI=1S/C29H48N12O12S2/c1-12(2)22-28(53)40-17(23(31)48)11-55-54-10-13(30)24(49)35-8-18(42)37-14(4-3-5-34-29(32)33)25(50)36-9-19(43)38-15(6-20(44)45)26(51)39-16(7-21(46)47)27(52)41-22/h12-17,22H,3-11,30H2,1-2H3,(H2,31,48)(H,35,49)(H,36,50)(H,37,42)(H,38,43)(H,39,51)(H,40,53)(H,41,52)(H,44,45)(H,46,47)(H4,32,33,34)/t13-,14+,15+,16-,17-,22-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Dehydroabietic acid} site|{Dehydroabietic acid} Anti-infection|{Dehydroabietic acid} Purity & Documentation|{Dehydroabietic acid} Formula|{Dehydroabietic acid} manufacturer|{Dehydroabietic acid} Cancer} |Shelf Life: ≥12 months if stored properly.{{Etripamil} medchemexpress|{Etripamil} Membrane Transporter/Ion Channel|{Etripamil} Biological Activity|{Etripamil} Purity|{Etripamil} manufacturer|{Etripamil} Cancer} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:25959043 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|LXW7 specially binds to αvβ3 integrin (Kd=76±10 nM). LXW7 binds strongly to αvβ3-K562 cells, weakly to αvβ5-K562 cells and αIIbβ3-K562 cells, and no binding to K562 cells. LXW7 has great potential as a highly efficient peptide ligand for targeted imaging and drug delivery. LXW7 acts as a potent and specific endothelial progenitor cells (EPCs) and endothelial cells (ECs) targeting ligand.|In Vivo:|LXW7 (100 μg/kg; intravenous injection) significantly lowers infarct volumes and brain water content (BWC) LXW7-treated rats. The LXW7 treatment lowers the expression of pro-inflammatory cytokines.|Products are for research use only. Not for human use.|