Product Name :
LIT-001 free base
Description:
LIT-001 free base is the first nonpeptide oxytocin receptor (OT-R) agonist (EC50=55 nM; Ki=226 nM). LIT-001 free base improves social interaction in a mouse model of autism.
CAS:
2245072-20-0
Molecular Weight:
531.67
Formula:
C28H33N7O2S
Chemical Name:
(2S)-2-(dimethylcarbamothioyl)-N-[(2-methyl-4-{4-methyl-2,4,5,9-tetraazatricyclo[8.4.0.0³,⁷]tetradeca-1(14),3(7),5,10,12-pentaene-9-carbonyl}phenyl)methyl]pyrrolidine-1-carboxamide
Smiles :
CN(C)C(=S)[C@@H]1CCCN1C(=O)NCC1=CC=C(C=C1C)C(=O)N1CC2C=NN(C)C=2NC2=CC=CC=C12
InChiKey:
AOPORIRPXVMWSL-DEOSSOPVSA-N
InChi :
InChI=1S/C28H33N7O2S/c1-18-14-19(11-12-20(18)15-29-28(37)34-13-7-10-24(34)27(38)32(2)3)26(36)35-17-21-16-30-33(4)25(21)31-22-8-5-6-9-23(22)35/h5-6,8-9,11-12,14,16,24,31H,7,10,13,15,17H2,1-4H3,(H,29,37)/t24-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
LIT-001 free base is the first nonpeptide oxytocin receptor (OT-R) agonist (EC50=55 nM; Ki=226 nM).{{Sildenafil} MedChemExpress|{Sildenafil} Autophagy|{Sildenafil} Technical Information|{Sildenafil} In Vitro|{Sildenafil} supplier|{Sildenafil} Autophagy} LIT-001 free base improves social interaction in a mouse model of autism.{{Nateglinide} MedChemExpress|{Nateglinide} Metabolic Enzyme/Protease|{Nateglinide} Protocol|{Nateglinide} Data Sheet|{Nateglinide} supplier|{Nateglinide} Autophagy} |Product information|CAS Number: 2245072-20-0|Molecular Weight: 531.PMID:28038441 67|Formula: C28H33N7O2S|Chemical Name: (2S)-2-(dimethylcarbamothioyl)-N-[(2-methyl-4-{4-methyl-2,4,5,9-tetraazatricyclo[8.4.0.0³,⁷]tetradeca-1(14),3(7),5,10,12-pentaene-9-carbonyl}phenyl)methyl]pyrrolidine-1-carboxamide|Smiles: CN(C)C(=S)[C@@H]1CCCN1C(=O)NCC1=CC=C(C=C1C)C(=O)N1CC2C=NN(C)C=2NC2=CC=CC=C12|InChiKey: AOPORIRPXVMWSL-DEOSSOPVSA-N|InChi: InChI=1S/C28H33N7O2S/c1-18-14-19(11-12-20(18)15-29-28(37)34-13-7-10-24(34)27(38)32(2)3)26(36)35-17-21-16-30-33(4)25(21)31-22-8-5-6-9-23(22)35/h5-6,8-9,11-12,14,16,24,31H,7,10,13,15,17H2,1-4H3,(H,29,37)/t24-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|In vitro signaling experiments, LIT-001 free base is a nonbiased OT-R agonist on the two main signaling pathways of this receptor, with minor antagonist effect on V1a and agonist effect on V1b receptors, observed at high concentrations only.|In Vivo:|LIT-001 free base (10-20 mg/kg; i.p.) alleviates core symptoms in the context of autism spectrum disorders (ASD ).|Products are for research use only. Not for human use.|
