Product Name: AFAP1 Antibody
Species Reactivity: Human, Mouse
Tested Applications: ELISA, WB
Applications: AFAP1 antibody can be used for detection of AFAP1 by Western blot at 1 – 2 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: AFAP1 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human AFAP1.The immunogen is located within amino acids 30 – 80 of AFAP1.
Host Species: Rabbit
Purification: AFAP1 Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 1093119-54-0
Product: MKC3946
Buffer: AFAP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: AFAP1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: AFAP1 Antibody: AFAP, AFAP110, AFAP-110, AFAP, Actin filament-associated protein 1, 110 kDa actin filament-associated protein
Accession NO.: NP_940997
Protein Ino: 197382472
Official Symbol: AFAP1
Geneid: 60312
Background: AFAP1 Antibody: The actin filament-associated protein AFAP1 (AFAP-110) is an actin cross-linking protein first identified as a substrate of the viral oncogene v-Src. AFAP1 has a fundamental role in actin cytoskeleton arrangement. It contains a carboxyterminal actin-binding domain that directly binds to F-actin and serves as an adaptor protein in the regulation of SRC and PKC signal transduction by several functional domains, including 2 pleckstrin homology (PH) domains, a Src homology 3-binding (SH3-binding) motif, and several SH2-binding motifs. It is overexpressed in prostate carcinoma and contributes to tumor growth by regulating cell-matrix adhesions and migration in the cancer cells. AFAP1 represent a possible therapeutic target for controlling tumorigenesis and metastasis.
PubMed ID:http://aac.asm.org/content/52/5/1799.abstract
