Product Name :
m-PEG5-succinimidyl carbonate
Description:
m-PEG5-succinimidyl carbonate is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG5-succinimidyl carbonate is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.
CAS:
1058691-00-1
Molecular Weight:
393.39
Formula:
C16H27NO10
Chemical Name:
2,5-dioxopyrrolidin-1-yl 2,5,8,11,14-pentaoxahexadecan-16-yl carbonate
Smiles :
COCCOCCOCCOCCOCCOC(=O)ON1C(=O)CCC1=O
InChiKey:
ZQIGTCCMJKPNRJ-UHFFFAOYSA-N
InChi :
InChI=1S/C16H27NO10/c1-21-4-5-22-6-7-23-8-9-24-10-11-25-12-13-26-16(20)27-17-14(18)2-3-15(17)19/h2-13H2,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Trilexium} medchemexpress|{Trilexium} Cytoskeleton|{Trilexium} Purity & Documentation|{Trilexium} In Vivo|{Trilexium} custom synthesis|{Trilexium} Epigenetic Reader Domain}
Shelf Life:
≥12 months if stored properly.{{Posaconazole} MedChemExpress|{Posaconazole} Parasite|{Posaconazole} Technical Information|{Posaconazole} Formula|{Posaconazole} custom synthesis|{Posaconazole} Cancer}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
m-PEG5-succinimidyl carbonate is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG5-succinimidyl carbonate is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.|Product information|CAS Number: 1058691-00-1|Molecular Weight: 393.39|Formula: C16H27NO10|Chemical Name: 2,5-dioxopyrrolidin-1-yl 2,5,8,11,14-pentaoxahexadecan-16-yl carbonate|Smiles: COCCOCCOCCOCCOCCOC(=O)ON1C(=O)CCC1=O|InChiKey: ZQIGTCCMJKPNRJ-UHFFFAOYSA-N|InChi: InChI=1S/C16H27NO10/c1-21-4-5-22-6-7-23-8-9-24-10-11-25-12-13-26-16(20)27-17-14(18)2-3-15(17)19/h2-13H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:24187611 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|References:|An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.Products are for research use only. Not for human use.|
