Product Name :
LEO 39652
Description:
LEO 39652 is a dual-soft PDE4 inhibitor with IC50s of 1.2 nM, 1.2 nM, 3.0 nM and 3.8 nM for PDE4A, PDE4B, PDE4C and PDE4D, respectively. LEO 39652 also inhibits TNF-α with an IC50 value of 6.0 nM. LEO 39652 is used for topical research of Atopic dermatitis (AD) .
CAS:
1445656-91-6
Molecular Weight:
421.45
Formula:
C23H23N3O5
Chemical Name:
2-methylpropyl 1-[8-methoxy-5-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropane-1-carboxylate
Smiles :
COC1=CC=C(C2=CC3COC(=O)C=3C=C2)N2N=C(N=C21)C1(CC1)C(=O)OCC(C)C
InChiKey:
LUUUHUYQTLUIDG-UHFFFAOYSA-N
InChi :
InChI=1S/C23H23N3O5/c1-13(2)11-31-22(28)23(8-9-23)21-24-19-18(29-3)7-6-17(26(19)25-21)14-4-5-16-15(10-14)12-30-20(16)27/h4-7,10,13H,8-9,11-12H2,1-3H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{L-Ascorbic acid} web|{L-Ascorbic acid} Immunology/Inflammation|{L-Ascorbic acid} Protocol|{L-Ascorbic acid} In Vivo|{L-Ascorbic acid} supplier|{L-Ascorbic acid} Epigenetic Reader Domain}
Shelf Life:
≥12 months if stored properly.{{7α-Hydroxycholesterol} medchemexpress|{7α-Hydroxycholesterol} Purity & Documentation|{7α-Hydroxycholesterol} Purity|{7α-Hydroxycholesterol} supplier|{7α-Hydroxycholesterol} Cancer}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
LEO 39652 is a dual-soft PDE4 inhibitor with IC50s of 1.2 nM, 1.2 nM, 3.0 nM and 3.8 nM for PDE4A, PDE4B, PDE4C and PDE4D, respectively. LEO 39652 also inhibits TNF-α with an IC50 value of 6.0 nM. LEO 39652 is used for topical research of Atopic dermatitis (AD) .|Product information|CAS Number: 1445656-91-6|Molecular Weight: 421.45|Formula: C23H23N3O5|Chemical Name: 2-methylpropyl 1-[8-methoxy-5-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropane-1-carboxylate|Smiles: COC1=CC=C(C2=CC3COC(=O)C=3C=C2)N2N=C(N=C21)C1(CC1)C(=O)OCC(C)C|InChiKey: LUUUHUYQTLUIDG-UHFFFAOYSA-N|InChi: InChI=1S/C23H23N3O5/c1-13(2)11-31-22(28)23(8-9-23)21-24-19-18(29-3)7-6-17(26(19)25-21)14-4-5-16-15(10-14)12-30-20(16)27/h4-7,10,13H,8-9,11-12H2,1-3H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 25 mg/mL (59.PMID:24013184 32 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|LEO 39652 shows unbound in vitro potency when measured as LPS induced TNF-α release in human peripheral blood mononuclear cells (PBMC), incubated in serum free medium. LEO 39652 shows a relatively high binding to human serum albumin.|In Vivo:|LEO 39652 is inactivated both in blood and liver (dual-soft) while stabled in the skin.Pharmacokinetic Analysis LEO 39652 exhibits total clearance (rats 930, minipigs 200 and monkey 300 mL/min/kg) and ratio to total AUC (rats 4, minipigs 6 and monkey 6 %) following intravenous administration (rats 0.075, minipigs 0.5 and monkeys 2.0 mg/kg).|Products are for research use only. Not for human use.|
