Product Name :
ELN318463
Description:
ELN318463 is an amyloid precursor protein (APP) selective γ-secretase inhibitor. ELN318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12 nM and 656 nM for PS1 and PS2, respectively. ELN318463 is 51-fold more selective for PS1.
CAS:
851600-86-7
Molecular Weight:
471.80
Formula:
C19H20BrClN2O3S
Chemical Name:
N-[(4-bromophenyl)methyl]-4-chloro-N-[(3R)-2-oxoazepan-3-yl]benzene-1-sulfonamide
Smiles :
O=C1NCCCC[C@H]1N(CC1C=CC(Br)=CC=1)S(=O)(=O)C1C=CC(Cl)=CC=1
InChiKey:
KTCJYACFOQWRDO-GOSISDBHSA-N
InChi :
InChI=1S/C19H20BrClN2O3S/c20-15-6-4-14(5-7-15)13-23(18-3-1-2-12-22-19(18)24)27(25,26)17-10-8-16(21)9-11-17/h4-11,18H,1-3,12-13H2,(H,22,24)/t18-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
ELN318463 is an amyloid precursor protein (APP) selective γ-secretase inhibitor. ELN318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12 nM and 656 nM for PS1 and PS2, respectively. ELN318463 is 51-fold more selective for PS1.|Product information|CAS Number: 851600-86-7|Molecular Weight: 471.80|Formula: C19H20BrClN2O3S|Chemical Name: N-[(4-bromophenyl)methyl]-4-chloro-N-[(3R)-2-oxoazepan-3-yl]benzene-1-sulfonamide|Smiles: O=C1NCCCC[C@H]1N(CC1C=CC(Br)=CC=1)S(=O)(=O)C1C=CC(Cl)=CC=1|InChiKey: KTCJYACFOQWRDO-GOSISDBHSA-N|InChi: InChI=1S/C19H20BrClN2O3S/c20-15-6-4-14(5-7-15)13-23(18-3-1-2-12-22-19(18)24)27(25,26)17-10-8-16(21)9-11-17/h4-11,18H,1-3,12-13H2,(H,22,24)/t18-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 125 mg/mL (264.{{Octreotide} site|{Octreotide} GPCR/G Protein|{Octreotide} Biological Activity|{Octreotide} In stock|{Octreotide} custom synthesis|{Octreotide} Autophagy} 94 mM; Need ultrasonic).{{Boceprevir} site|{Boceprevir} HCV|{Boceprevir} Protocol|{Boceprevir} Description|{Boceprevir} manufacturer|{Boceprevir} Epigenetics} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:24507727 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|ELN318463 behaves as a classic γ-secretase inhibitor, demonstrates 75- to 120-fold selectivity for inhibiting Aβ production compared with Notch signaling in cells, and displaces an active site directed inhibitor at very high concentrations only in the presence of substrate.|In Vivo:|ELN318463 (30 mg/kg or 100 mg/kg; orally) leads acute reduction of brain Aβ in in the PDAPP transgene model of Alzheimer’s disease (AD) as well as in wild-type FVB strain mice.|Products are for research use only. Not for human use.|
