anti-ttk mouse mab

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Recombinant Anti-TTK Mouse mAb Clone Number: JMMR-3601 Host: Mouse Clonality: Recombinant Monoclonal Applications： WB Reactivity: Human Synonyms: MPS1, MPS1L1 Product Size 100 μl ADD TO CART BUY NOW Quantity Shipping: Ambient temperature Order online or send purchase order to [email protected] FAQ Technical Support Protocols General Information Product Usage Information Properties Target Information Images Recommended Products References BUY NOW General Information Isotype IgG1/kappa Conjugate Unconjugated Synonyms MPS1, MPS1L1 UniProt ID P33981 Immunogen MW (kDa) Specificity Product Usage Information Applications Dilution Recommended Species WB 1:1000 Human Properties Purity Protein A purified Constituents PBS, Glycerol, BSA Storage Store at -20°C. Avoid freeze/thaw cycles. Stability Stable for 12 months from date of receipt/reconstitution. Target Information Background TTK also named as Mps1 or PYT, is a cell cycle regulated dual specificity kinase present in rapidly proliferating tissues and cell lines. TTK localizes to kinetochores and centromeres and is an essential component of the mitotic spindle checkpoint as well as centrosome duplication. The mitotic checkpoint inhibits entry into anaphase until all chromosomes are attached to the spindle; inhibition of this process leads to genomic instability and tumorigenesis. Phosphorylation of the BLM helicase at Ser144 by TTK maintains chromosome stability during mitosis. Small molecule inhibitors of TTK can block the spindle checkpoint response, thereby making TTK a potential therapeutic target. Cellular location Cytoskeleton, Nucleus, Cytoplasm Images WB Blocking buffer: 5% NFDM/TBST Primary Ab dilution: 1:1000 Primary Ab incubation condition: 2 hours at room temperature Secondary Ab: Goat Anti-Mouse IgGH&L(HRP Conjugate) Lysate: 1: HeLa, 2: Ramos Protein loading quantity: 20 μg Exposure time: 60 secondsPredicted band size: 97 kDa Observed band size: 100 kDa :
Recombinant Anti-TTK Mouse mAb Clone Number: JMMR-3601 Host: Mouse Clonality: Recombinant Monoclonal Applications： WB Reactivity: Human Synonyms: MPS1, MPS1L1 Product Size 100 μl ADD TO CART BUY NOW Quantity Shipping: Ambient temperature Order online or send purchase order to [email protected] FAQ Technical Support Protocols General Information Product Usage Information Properties Target Information Images Recommended Products References BUY NOW General Information Isotype IgG1/kappa Conjugate Unconjugated Synonyms MPS1, MPS1L1 UniProt ID P33981 Immunogen MW (kDa) Specificity Product Usage Information Applications Dilution Recommended Species WB 1:1000 Human Properties Purity Protein A purified Constituents PBS, Glycerol, BSA Storage Store at -20°C. Avoid freeze/thaw cycles. Stability Stable for 12 months from date of receipt/reconstitution. Target Information Background TTK also named as Mps1 or PYT, is a cell cycle regulated dual specificity kinase present in rapidly proliferating tissues and cell lines. TTK localizes to kinetochores and centromeres and is an essential component of the mitotic spindle checkpoint as well as centrosome duplication. The mitotic checkpoint inhibits entry into anaphase until all chromosomes are attached to the spindle; inhibition of this process leads to genomic instability and tumorigenesis. Phosphorylation of the BLM helicase at Ser144 by TTK maintains chromosome stability during mitosis. Small molecule inhibitors of TTK can block the spindle checkpoint response, thereby making TTK a potential therapeutic target. Cellular location Cytoskeleton, Nucleus, Cytoplasm Images WB Blocking buffer: 5% NFDM/TBST Primary Ab dilution: 1:1000 Primary Ab incubation condition: 2 hours at room temperature Secondary Ab: Goat Anti-Mouse IgGH&L(HRP Conjugate) Lysate: 1: HeLa, 2: Ramos Protein loading quantity: 20 μg Exposure time: 60 secondsPredicted band size: 97 kDa Observed band size: 100 kDa