anti-trim56 rabbit pab

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Anti-TRIM56 Rabbit pAb Clone Number: / Host: Rabbit Clonality: Polyclonal Applications： WB Reactivity: Human Synonyms: RNF109 Product Size 100 μl ADD TO CART BUY NOW Quantity Shipping: Ambient temperature Order online or send purchase order to [email protected] FAQ Technical Support Protocols General Information Product Usage Information Properties Target Information Images Recommended Products References BUY NOW General Information Isotype IgG Conjugate Unconjugated Synonyms RNF109 UniProt ID Q9BRZ2 Immunogen MW (kDa) Specificity Product Usage Information Applications Dilution Recommended Species WB 1:1000 Human Properties Purity Protein A and immunogen affinity purified Constituents PBS, Glycerol, BSA Storage Store at -20°C. Avoid freeze/thaw cycles. Stability Stable for 12 months from date of receipt/reconstitution. Target Information Background Tripartite motif-containing protein 56 (TRIM56), also named as RNF109, is a E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity by mediating ubiquitination of CGAS and STING. In response to pathogen- and host-derived double-stranded DNA (dsDNA), TRIM56 targets STING1 to ‘Lys-63’-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta. TRIM56 also mediate monoubiquitination of CGAS, thereby promoting CGAS oligomerization and subsequent activation. Independent of its E3 ubiquitin ligase activity, TRIM56 is a positive regulator of TLR3 signaling. TRIM56 also potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES. Cellular location Cytoplasm Images WB Blocking buffer: 5% NFDM/TBST Primary Ab dilution: 1:1000 Primary Ab incubation condition: 2 hours at room temperature Secondary Ab: Goat Anti-Rabbit IgGH&L (HRP Conjugate) Lysate: 1: SW480, 2: A375, 3: HeLa Protein loading amount: 20 μg Exposure time: 60 secondsPredicted band size: 81 kDa Observed band size: 81 kDa :
Anti-TRIM56 Rabbit pAb Clone Number: / Host: Rabbit Clonality: Polyclonal Applications： WB Reactivity: Human Synonyms: RNF109 Product Size 100 μl ADD TO CART BUY NOW Quantity Shipping: Ambient temperature Order online or send purchase order to [email protected] FAQ Technical Support Protocols General Information Product Usage Information Properties Target Information Images Recommended Products References BUY NOW General Information Isotype IgG Conjugate Unconjugated Synonyms RNF109 UniProt ID Q9BRZ2 Immunogen MW (kDa) Specificity Product Usage Information Applications Dilution Recommended Species WB 1:1000 Human Properties Purity Protein A and immunogen affinity purified Constituents PBS, Glycerol, BSA Storage Store at -20°C. Avoid freeze/thaw cycles. Stability Stable for 12 months from date of receipt/reconstitution. Target Information Background Tripartite motif-containing protein 56 (TRIM56), also named as RNF109, is a E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity by mediating ubiquitination of CGAS and STING. In response to pathogen- and host-derived double-stranded DNA (dsDNA), TRIM56 targets STING1 to ‘Lys-63’-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta. TRIM56 also mediate monoubiquitination of CGAS, thereby promoting CGAS oligomerization and subsequent activation. Independent of its E3 ubiquitin ligase activity, TRIM56 is a positive regulator of TLR3 signaling. TRIM56 also potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES. Cellular location Cytoplasm Images WB Blocking buffer: 5% NFDM/TBST Primary Ab dilution: 1:1000 Primary Ab incubation condition: 2 hours at room temperature Secondary Ab: Goat Anti-Rabbit IgGH&L (HRP Conjugate) Lysate: 1: SW480, 2: A375, 3: HeLa Protein loading amount: 20 μg Exposure time: 60 secondsPredicted band size: 81 kDa Observed band size: 81 kDa