anti-p75 ngf receptor rabbit mab

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Recombinant Rabbit Monoclonal Anti-p75 NGF Receptor Rabbit mAb Clone Number: JRMR-10513-71 Host: Rabbit Clonality: Monoclonal Applications： WB、IHC-P、ICC/IF、FC Reactivity: Human, Rat Synonyms: p75NTR, NGFR, CD271, NGF Receptor Product Size 100 μl ADD TO CART BUY NOW Quantity Shipping: Ambient temperature Order online or send purchase order to [email protected] FAQ Technical Support Protocols General Information Product Usage Information Properties Target Information Images Recommended Products References BUY NOW General Information Isotype IgG Conjugate Unconjugated Synonyms p75NTR, NGFR, CD271, NGF Receptor UniProt ID P08138 Immunogen MW (kDa) Specificity Product Usage Information Applications Dilution Recommended Species WB 1:500-1:2000 Human, Rat IHC-P 1:100-1:1000 Human ICC/IF 1:50 Rat FC 1:50-1:100 Rat Properties Purity Protein A purified Constituents PBS, Glycerol, BSA Storage Store at -20°C. Avoid freeze/thaw cycles. Stability Stable for 12 months from date of receipt/reconstitution. Target Information Background Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF. Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver. Cellular location Membrane, Cytoplasm Images WB Blocking buffer: 5% NFDM/TBSTPrimary Ab dilution: 1:2000Primary Ab incubation condition: 2 hours at room temperatureSecondary Ab: Goat Anti-Rabbit IgG H&L (HRP)Lysate: 1: SW480, 2: PC-12Protein loading quantity: 20 μgExposure time: 60 sPredicted MW: 45 kDaObserved MW: 70 kDa IHC-P Tissue: Human prostatic hyperplasiaSection type: Formalin-fixed & Paraffin- embedded section Retrieval method: High temperature and high pressureRetrieval buffer: Tris/EDTA buffer, pH 9.0 Primary Ab dilution: 1:1000Primary Ab incubation condition: 1 hour at room temperature Secondary Ab: Anti-Rabbit and Mouse Polymer HRP (Ready to use)Counter stain: Hematoxylin (Blue)Comment: Color brown is the positive signal for :
Recombinant Rabbit Monoclonal Anti-p75 NGF Receptor Rabbit mAb Clone Number: JRMR-10513-71 Host: Rabbit Clonality: Monoclonal Applications： WB、IHC-P、ICC/IF、FC Reactivity: Human, Rat Synonyms: p75NTR, NGFR, CD271, NGF Receptor Product Size 100 μl ADD TO CART BUY NOW Quantity Shipping: Ambient temperature Order online or send purchase order to [email protected] FAQ Technical Support Protocols General Information Product Usage Information Properties Target Information Images Recommended Products References BUY NOW General Information Isotype IgG Conjugate Unconjugated Synonyms p75NTR, NGFR, CD271, NGF Receptor UniProt ID P08138 Immunogen MW (kDa) Specificity Product Usage Information Applications Dilution Recommended Species WB 1:500-1:2000 Human, Rat IHC-P 1:100-1:1000 Human ICC/IF 1:50 Rat FC 1:50-1:100 Rat Properties Purity Protein A purified Constituents PBS, Glycerol, BSA Storage Store at -20°C. Avoid freeze/thaw cycles. Stability Stable for 12 months from date of receipt/reconstitution. Target Information Background Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF. Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver. Cellular location Membrane, Cytoplasm Images WB Blocking buffer: 5% NFDM/TBSTPrimary Ab dilution: 1:2000Primary Ab incubation condition: 2 hours at room temperatureSecondary Ab: Goat Anti-Rabbit IgG H&L (HRP)Lysate: 1: SW480, 2: PC-12Protein loading quantity: 20 μgExposure time: 60 sPredicted MW: 45 kDaObserved MW: 70 kDa IHC-P Tissue: Human prostatic hyperplasiaSection type: Formalin-fixed & Paraffin- embedded section Retrieval method: High temperature and high pressureRetrieval buffer: Tris/EDTA buffer, pH 9.0 Primary Ab dilution: 1:1000Primary Ab incubation condition: 1 hour at room temperature Secondary Ab: Anti-Rabbit and Mouse Polymer HRP (Ready to use)Counter stain: Hematoxylin (Blue)Comment: Color brown is the positive signal for