anti-klf4 rabbit mab

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Recombinant Rabbit Monoclonal Anti-KLF4 Rabbit mAb Clone Number: JRMR-10010-21H1L1 Host: Rabbit Clonality: Recombinant Monoclonal Applications： IHC-P ICC/IF Reactivity: Human, Mouse, Rat Synonyms: EZF, GKLF Product Size 100 μl ADD TO CART BUY NOW Quantity Shipping: Ambient temperature Order online or send purchase order to [email protected] FAQ Technical Support Protocols General Information Product Usage Information Properties Target Information Images Recommended Products References BUY NOW General Information Isotype IgG Conjugate Unconjugated Synonyms EZF, GKLF UniProt ID O43474 Immunogen MW (kDa) Specificity Product Usage Information Applications Dilution Recommended Species IHC-P 1:200 – 1:1000 Human, Mouse, Rat ICC/IF 1:50 Mouse Properties Purity Protein A purified Constituents PBS, Glycerol, BSA Storage Store at -20°C. Avoid freeze/thaw cycles. Stability Stable for 12 months from date of receipt/reconstitution. Target Information Background KLF4 belongs to the kruppel transcription factor family, which binds to the 5′-CACCC-3′ core sequence, acting as both an activator and an inhibitor. KLF4 binds to the promoter region of its own genes and can activate its own transcription. KLF4 regulates the expression of key transcription factors during embryonic development and regulates the maintenance and differentiation of embryonic stem cells; KLF4 contributes to the down- regulation of p53/TP53 transcription and is a key regulator of normal cell proliferation. It can inhibit the proliferation of neuroblastoma, pancreatic cancer, colorectal cancer, hepatocellular carcinoma, et al. For example, in human pancreatic cancer, KLF4 reduces tumor cell proliferation by inducing the CDK inhibitors CDKN1A and CDKN1B (encoding p27; also known as KIP1) and reducing the expression of cyclin D1 (CCND1) and FOXM1. Cellular location Nucleus Images IHC-P Tissue: Human colonSection type: Formalin fixed & Paraffin -embedded section Retrieval method: High temperature and high pressureRetrieval buffer: Tris/EDTA buffer, pH 9.0 Primary Ab dilution: 1: 1000Primary Ab incubation condition: 1 hour at room temperature Counter stain: HematoxylinDescription: The brown color represents the positive signal observed with :
Recombinant Rabbit Monoclonal Anti-KLF4 Rabbit mAb Clone Number: JRMR-10010-21H1L1 Host: Rabbit Clonality: Recombinant Monoclonal Applications： IHC-P ICC/IF Reactivity: Human, Mouse, Rat Synonyms: EZF, GKLF Product Size 100 μl ADD TO CART BUY NOW Quantity Shipping: Ambient temperature Order online or send purchase order to [email protected] FAQ Technical Support Protocols General Information Product Usage Information Properties Target Information Images Recommended Products References BUY NOW General Information Isotype IgG Conjugate Unconjugated Synonyms EZF, GKLF UniProt ID O43474 Immunogen MW (kDa) Specificity Product Usage Information Applications Dilution Recommended Species IHC-P 1:200 – 1:1000 Human, Mouse, Rat ICC/IF 1:50 Mouse Properties Purity Protein A purified Constituents PBS, Glycerol, BSA Storage Store at -20°C. Avoid freeze/thaw cycles. Stability Stable for 12 months from date of receipt/reconstitution. Target Information Background KLF4 belongs to the kruppel transcription factor family, which binds to the 5′-CACCC-3′ core sequence, acting as both an activator and an inhibitor. KLF4 binds to the promoter region of its own genes and can activate its own transcription. KLF4 regulates the expression of key transcription factors during embryonic development and regulates the maintenance and differentiation of embryonic stem cells; KLF4 contributes to the down- regulation of p53/TP53 transcription and is a key regulator of normal cell proliferation. It can inhibit the proliferation of neuroblastoma, pancreatic cancer, colorectal cancer, hepatocellular carcinoma, et al. For example, in human pancreatic cancer, KLF4 reduces tumor cell proliferation by inducing the CDK inhibitors CDKN1A and CDKN1B (encoding p27; also known as KIP1) and reducing the expression of cyclin D1 (CCND1) and FOXM1. Cellular location Nucleus Images IHC-P Tissue: Human colonSection type: Formalin fixed & Paraffin -embedded section Retrieval method: High temperature and high pressureRetrieval buffer: Tris/EDTA buffer, pH 9.0 Primary Ab dilution: 1: 1000Primary Ab incubation condition: 1 hour at room temperature Counter stain: HematoxylinDescription: The brown color represents the positive signal observed with