Product Name :
anti-kdm2a rabbit mab
Isotype :
IgG/kappa
Conjugate :
Unconjugated
Synonyms:
CXXC8, FBL11, FBL7, FBXL11, JHDM1A, KIAA1004
UniProt ID :
Q9Y2K7
Immunogen:
MW (kDa) :
Specificity:
Purity :
Protein G purified
Purity :
PBS, Glycerol, BSA
Storage :
Store at -20°C. Avoid freeze/thaw cycles.
Stability:
Stable for 12 months from date of receipt/reconstitution.
Background :
Histone demethylase that specifically demethylates ‘Lys-36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ‘Lys-36’ residue while it has weak or no activity for mono- and Trimethylated H3 ‘Lys-36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-ARNTL/BMAL1 heterodimer and RORA in a catalytically-independent manner. Cellular location Nucleus
Images :
WB Blocking buffer: 5% NFDM/TBSTPrimary Ab dilution: 1:5000Primary Ab incubation condition: 2 hours at room temperatureSecondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)Lysate: 1: HeLa, 2: MCF7, 3: SK-BR-3, 4: 4T1Protein loading quantity: 20 μgExposure time: 10 sPredicted band size: 133 kDaObserved band size: 140 kDa IHC-P Tissue: Rat colonSection type: Formalin fixed & Paraffin -embedded section Retrieval method: High temperature and high pressureRetrieval buffer: Tris/EDTA buffer, pH 9.0 Primary Ab dilution: 1:100Primary Ab incubation condition: 1 hour at room temperature Secondary Ab: Anti-Rabbit and Mouse Polymer HRP (Ready to Use)Counter stain: Hematoxylin (Blue)Description: The brown color represents the positive signal observed with
Vapor Pressure :
Recombinant Rabbit Monoclonal Anti-KDM2A Rabbit mAb Clone Number: 12088 Host: Rabbit Clonality: Recombinant Monoclonal Applications： WB IHC-P ICC/IF Reactivity: Human, Mouse, Rat Synonyms: CXXC8, FBL11, FBL7, FBXL11, JHDM1A, KIAA1004 Product Size 100 μl ADD TO CART BUY NOW Quantity Shipping: Ambient temperature Order online or send purchase order to [email protected] FAQ Technical Support Protocols General Information Product Usage Information Properties Target Information Images Recommended Products References BUY NOW General Information Isotype IgG/kappa Conjugate Unconjugated Synonyms CXXC8, FBL11, FBL7, FBXL11, JHDM1A, KIAA1004 UniProt ID Q9Y2K7 Immunogen MW (kDa) Specificity Product Usage Information Applications Dilution Recommended Species WB 1:1000 – 1:5000 Human, Mouse IHC-P 1:50 – 1:100 Rat ICC/IF 1:50 Human Properties Purity Protein G purified Constituents PBS, Glycerol, BSA Storage Store at -20°C. Avoid freeze/thaw cycles. Stability Stable for 12 months from date of receipt/reconstitution. Target Information Background Histone demethylase that specifically demethylates ‘Lys-36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ‘Lys-36’ residue while it has weak or no activity for mono- and Trimethylated H3 ‘Lys-36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-ARNTL/BMAL1 heterodimer and RORA in a catalytically-independent manner. Cellular location Nucleus Images WB Blocking buffer: 5% NFDM/TBSTPrimary Ab dilution: 1:5000Primary Ab incubation condition: 2 hours at room temperatureSecondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)Lysate: 1: HeLa, 2: MCF7, 3: SK-BR-3, 4: 4T1Protein loading quantity: 20 μgExposure time: 10 sPredicted band size: 133 kDaObserved band size: 140 kDa IHC-P Tissue: Rat colonSection type: Formalin fixed & Paraffin -embedded section Retrieval method: High temperature and high pressureRetrieval buffer: Tris/EDTA buffer, pH 9.0 Primary Ab dilution: 1:100Primary Ab incubation condition: 1 hour at room temperature Secondary Ab: Anti-Rabbit and Mouse Polymer HRP (Ready to Use)Counter stain: Hematoxylin (Blue)Description: The brown color represents the positive signal observed with
Recombinant Rabbit Monoclonal Anti-KDM2A Rabbit mAb Clone Number: 12088 Host: Rabbit Clonality: Recombinant Monoclonal Applications： WB IHC-P ICC/IF Reactivity: Human, Mouse, Rat Synonyms: CXXC8, FBL11, FBL7, FBXL11, JHDM1A, KIAA1004 Product Size 100 μl ADD TO CART BUY NOW Quantity Shipping: Ambient temperature Order online or send purchase order to [email protected] FAQ Technical Support Protocols General Information Product Usage Information Properties Target Information Images Recommended Products References BUY NOW General Information Isotype IgG/kappa Conjugate Unconjugated Synonyms CXXC8, FBL11, FBL7, FBXL11, JHDM1A, KIAA1004 UniProt ID Q9Y2K7 Immunogen MW (kDa) Specificity Product Usage Information Applications Dilution Recommended Species WB 1:1000 – 1:5000 Human, Mouse IHC-P 1:50 – 1:100 Rat ICC/IF 1:50 Human Properties Purity Protein G purified Constituents PBS, Glycerol, BSA Storage Store at -20°C. Avoid freeze/thaw cycles. Stability Stable for 12 months from date of receipt/reconstitution. Target Information Background Histone demethylase that specifically demethylates ‘Lys-36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ‘Lys-36’ residue while it has weak or no activity for mono- and Trimethylated H3 ‘Lys-36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-ARNTL/BMAL1 heterodimer and RORA in a catalytically-independent manner. Cellular location Nucleus Images WB Blocking buffer: 5% NFDM/TBSTPrimary Ab dilution: 1:5000Primary Ab incubation condition: 2 hours at room temperatureSecondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)Lysate: 1: HeLa, 2: MCF7, 3: SK-BR-3, 4: 4T1Protein loading quantity: 20 μgExposure time: 10 sPredicted band size: 133 kDaObserved band size: 140 kDa IHC-P Tissue: Rat colonSection type: Formalin fixed & Paraffin -embedded section Retrieval method: High temperature and high pressureRetrieval buffer: Tris/EDTA buffer, pH 9.0 Primary Ab dilution: 1:100Primary Ab incubation condition: 1 hour at room temperature Secondary Ab: Anti-Rabbit and Mouse Polymer HRP (Ready to Use)Counter stain: Hematoxylin (Blue)Description: The brown color represents the positive signal observed with
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