anti-il-22 rabbit pab

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Anti-IL-22 Rabbit pAb Clone Number: / Host: Rabbit Clonality: Polyclonal Applications： WB Reactivity: Synonyms: Cytokine Zcyto18, IL-TIF Product Size 100 μl ADD TO CART BUY NOW Quantity Shipping: Ambient temperature Order online or send purchase order to [email protected] FAQ Technical Support Protocols General Information Product Usage Information Properties Target Information Images Recommended Products References BUY NOW General Information Isotype IgG Conjugate Unconjugated Synonyms Cytokine Zcyto18, IL-TIF UniProt ID Q9GZX6 Immunogen MW (kDa) Specificity Product Usage Information Applications Dilution Recommended Species WB 1:500 – 1:1000 Recombinant protein Properties Purity Protein A and immunogen affinity purified Constituents PBS, Glycerol, BSA Storage Store at -20°C. Avoid freeze/thaw cycles. Stability Stable for 12 months from date of receipt/reconstitution. Target Information Background Interleukin-22 (IL-22), a member of the IL-10 family, is expressed by Th17 CD4+ T cells, activated T cells, Th1 cells, and NK cells. IL-22 induces proinflammatory responses, drives production of antimicrobial peptides, and is involved in tissue repair and wound healing responses. The IL-22 receptor is a heterodimer of IL-22R1 and IL-10R2. Expression of IL-22R is restricted to tissue-resident cells, particularly those of epithelial origin, whereas the IL-10R2 chain is expressed in many more cell types. IL-22 induces phosphorylation of Jak1 and Tyk2, leading to activation of Stat3 and, to a lesser extent, Stat1 and Stat5. IL-22 responses can involve activation of the MEK-ERK-RSK, JNK-SAPK, and p38 pathways. Elevated levels of IL-22 have been associated with Crohn’s disease and rheumatoid arthritis. IL-22 plays an essential role in host response to the pulmonary pathogen Klebsiella pneumoniae. Cellular location Secreted Images WB Blocking buffer: 5% NFDM/TBST Primary Ab dilution: 1:1000 Primary Ab incubation condition: 2 hours at room temperature Secondary Ab: Goat Anti-Rabbit IgGH&L (HRP Conjugate) Lysate: 1: IL22 recombinant protein Protein loading quantity: 100 ng Exposure time: 10 secondsPredicted band size: 20 kDa Observed band size: 15 kDa :
Anti-IL-22 Rabbit pAb Clone Number: / Host: Rabbit Clonality: Polyclonal Applications： WB Reactivity: Synonyms: Cytokine Zcyto18, IL-TIF Product Size 100 μl ADD TO CART BUY NOW Quantity Shipping: Ambient temperature Order online or send purchase order to [email protected] FAQ Technical Support Protocols General Information Product Usage Information Properties Target Information Images Recommended Products References BUY NOW General Information Isotype IgG Conjugate Unconjugated Synonyms Cytokine Zcyto18, IL-TIF UniProt ID Q9GZX6 Immunogen MW (kDa) Specificity Product Usage Information Applications Dilution Recommended Species WB 1:500 – 1:1000 Recombinant protein Properties Purity Protein A and immunogen affinity purified Constituents PBS, Glycerol, BSA Storage Store at -20°C. Avoid freeze/thaw cycles. Stability Stable for 12 months from date of receipt/reconstitution. Target Information Background Interleukin-22 (IL-22), a member of the IL-10 family, is expressed by Th17 CD4+ T cells, activated T cells, Th1 cells, and NK cells. IL-22 induces proinflammatory responses, drives production of antimicrobial peptides, and is involved in tissue repair and wound healing responses. The IL-22 receptor is a heterodimer of IL-22R1 and IL-10R2. Expression of IL-22R is restricted to tissue-resident cells, particularly those of epithelial origin, whereas the IL-10R2 chain is expressed in many more cell types. IL-22 induces phosphorylation of Jak1 and Tyk2, leading to activation of Stat3 and, to a lesser extent, Stat1 and Stat5. IL-22 responses can involve activation of the MEK-ERK-RSK, JNK-SAPK, and p38 pathways. Elevated levels of IL-22 have been associated with Crohn’s disease and rheumatoid arthritis. IL-22 plays an essential role in host response to the pulmonary pathogen Klebsiella pneumoniae. Cellular location Secreted Images WB Blocking buffer: 5% NFDM/TBST Primary Ab dilution: 1:1000 Primary Ab incubation condition: 2 hours at room temperature Secondary Ab: Goat Anti-Rabbit IgGH&L (HRP Conjugate) Lysate: 1: IL22 recombinant protein Protein loading quantity: 100 ng Exposure time: 10 secondsPredicted band size: 20 kDa Observed band size: 15 kDa