anti-il-18 mouse mab

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Recombinant Anti-IL-18 Mouse mAb Clone Number: JMMR-2351 Host: Mouse Clonality: Recombinant Monoclonal Applications： WB Reactivity: Human Synonyms: Iboctadekin, IL-1 gamma, IGIF, IL1F4 Product Size 100 μl ADD TO CART BUY NOW Quantity Shipping: Ambient temperature Order online or send purchase order to [email protected] FAQ Technical Support Protocols General Information Product Usage Information Properties Target Information Images Recommended Products References BUY NOW General Information Isotype IgG1/kappa Conjugate Unconjugated Synonyms Iboctadekin, IL-1 gamma, IGIF, IL1F4 UniProt ID Q14116 Immunogen MW (kDa) Specificity Product Usage Information Applications Dilution Recommended Species WB 1:500 – 1:1000 Human Properties Purity Protein A purified Constituents PBS, Glycerol, BSA Storage Store at -20°C. Avoid freeze/thaw cycles. Stability Stable for 12 months from date of receipt/reconstitution. Target Information Background Interleukin-18 (IL-18), also known as interferon-gamma inducing factor (IGIF), is part of the IL-superfamily of cytokines. This proinflammatory cytokine is synthesized as an inactive precursor which requires cleavage by Caspase-1 to become an active, mature molecule, which is secreted by monocytes and macrophages. It induces IFNγ production in T-helper-1 (Th1) cells and natural killer (NK) cells, and can regulate innate immunity via both Th1 and Th2 responses. Elevated IL-18 levels are associated with autoimmune disease, but may be balanced by binding to IL-18 binding protein (IL-18BP), which along with IL-18 neutralizing antibodies, are being examined in clinical trials. Cellular location Cytoplasm, Secreted Images WB Blocking buffer: 5% NFDM/TBST Primary Ab dilution: 1:1000 Primary Ab incubation condition: 2 hours at room temperature Secondary Ab: Goat Anti-Mouse IgG H&L pAb (HRP Conjugate) Lysate: 1: PC-3, 2: U-2 OS, 3: HeLa Protein loading quantity: 20 μg Exposure time: 60 secondsPredicted band size: 22 kDa Observed band size: 22 kDa :
Recombinant Anti-IL-18 Mouse mAb Clone Number: JMMR-2351 Host: Mouse Clonality: Recombinant Monoclonal Applications： WB Reactivity: Human Synonyms: Iboctadekin, IL-1 gamma, IGIF, IL1F4 Product Size 100 μl ADD TO CART BUY NOW Quantity Shipping: Ambient temperature Order online or send purchase order to [email protected] FAQ Technical Support Protocols General Information Product Usage Information Properties Target Information Images Recommended Products References BUY NOW General Information Isotype IgG1/kappa Conjugate Unconjugated Synonyms Iboctadekin, IL-1 gamma, IGIF, IL1F4 UniProt ID Q14116 Immunogen MW (kDa) Specificity Product Usage Information Applications Dilution Recommended Species WB 1:500 – 1:1000 Human Properties Purity Protein A purified Constituents PBS, Glycerol, BSA Storage Store at -20°C. Avoid freeze/thaw cycles. Stability Stable for 12 months from date of receipt/reconstitution. Target Information Background Interleukin-18 (IL-18), also known as interferon-gamma inducing factor (IGIF), is part of the IL-superfamily of cytokines. This proinflammatory cytokine is synthesized as an inactive precursor which requires cleavage by Caspase-1 to become an active, mature molecule, which is secreted by monocytes and macrophages. It induces IFNγ production in T-helper-1 (Th1) cells and natural killer (NK) cells, and can regulate innate immunity via both Th1 and Th2 responses. Elevated IL-18 levels are associated with autoimmune disease, but may be balanced by binding to IL-18 binding protein (IL-18BP), which along with IL-18 neutralizing antibodies, are being examined in clinical trials. Cellular location Cytoplasm, Secreted Images WB Blocking buffer: 5% NFDM/TBST Primary Ab dilution: 1:1000 Primary Ab incubation condition: 2 hours at room temperature Secondary Ab: Goat Anti-Mouse IgG H&L pAb (HRP Conjugate) Lysate: 1: PC-3, 2: U-2 OS, 3: HeLa Protein loading quantity: 20 μg Exposure time: 60 secondsPredicted band size: 22 kDa Observed band size: 22 kDa