Product Name: ACACA Antibody
Species Reactivity: Human
Tested Applications: WB
Applications: For WB starting dilution is: 1:1000
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 266 kDa
Immunogen: This ACACA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2010-2039 amino acids from the C-terminal region of human ACACA.
Host Species: Rabbit
Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
Physical State: Liquid
CAS NO.: 1632118-69-4
Product: BAR501
Buffer: Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration: 0.5 mg/ml
Storage Conditions: Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Acetyl-CoA carboxylase 1, ACC1, ACC-alpha, Biotin carboxylase, ACACA, ACAC, ACC1, ACCA
Accession NO.: Q13085
Protein Ino: 118601083
Official Symbol: ACACA
Geneid: 31
Background: Acetyl-CoA carboxylase (ACC) is a complex multifunctionalenzyme system. ACC is a biotin-containing enzyme which catalyzesthe carboxylation of acetyl-CoA to malonyl-CoA, the rate-limitingstep in fatty acid synthesis. There are two ACC forms, alpha andbeta, encoded by two different genes. ACC-alpha is highly enrichedin lipogenic tissues. The enzyme is under long term control at thetranscriptional and translational levels and under short termregulation by the phosphorylation/dephosphorylation of targetedserine residues and by allosteric transformation by citrate orpalmitoyl-CoA. Multiple alternatively spliced transcript variantsdivergent in the 5 sequence and encoding distinct isoforms havebeen found for this gene.
PubMed ID:http://aac.asm.org/content/52/1/237.abstract
