Ight help within the improvement of new-generation PARP NF-κB Biological Activity inhibitors with improved
Ight aid inside the improvement of new-generation PARP inhibitors with improved selectivity. We thank Drs Ying Feng, Daniel Chu and Leonard Post for their scientific knowledge and input. We gratefully acknowledge Dr Gordon Vehar for important comments on the manuscript. We in particular thank Tracy Arakaki, Thomas Edwards, Brandy Taylor, Ilyssa Exley, Jacob Statnekov, Shellie Dieterich and Jess Leonard (Emerald BioStructures) for the crystallographic function. MA-S, BKY, BW, YS and PAF are staff of, and have equity interest in, BioMarin Pharmaceutical Inc., that is building BMN 673 as a possible commercial therapeutic.Emsley, P. Cowtan, K. (2004). Acta Cryst. D60, 2126132. Emsley, P., Lohkamp, B., Scott, W. G. Cowtan, K. (2010). Acta Cryst. D66, 48601. Ferraris, D. V. (2010). J. Med. Chem. 53, 4561584. Gandhi, V. B., Luo, Y., Liu, X., Shi, Y., Klinghofer, V., Johnson, E. F., Park, C., Giranda, V. L., Penning, T. D. Zhu, G. D. (2010). Bioorg. Med. Chem. Lett. 20, 1023026. Gangloff, A. R., Brown, J., de Jong, R., Dougan, D. R., MT1 custom synthesis Grimshaw, C. E., Hixon, M., Jennings, A., Kamran, R., Kiryanov, A., O’Connell, S., Taylor, E. Vu, P. (2013). Bioorg. Med. Chem. Lett. 23, 4501505. Hassa, P. O. Hottiger, M. O. (2008). Front. Biosci. 13, 3046082. Hattori, K., Kido, Y., Yamamoto, H., Ishida, J., Kamijo, K., Murano, K., Ohkubo, M., Kinoshita, T., Iwashita, A., Mihara, K., Yamazaki, S., Matsuoka, N., Teramura, Y. Miyake, H. (2004). J. Med. Chem. 47, 4151154. Iwashita, A., Hattori, K., Yamamoto, H., Ishida, J., Kido, Y., Kamijo, K., Murano, K., Miyake, H., Kinoshita, T., Warizaya, M., Ohkubo, M., Matsuoka, N. Mutoh, S. (2005). FEBS Lett. 579, 1389393. Kabsch, W. (2010). Acta Cryst. D66, 12532. Karlberg, T., Hammarstrom, M., Schutz, P., Svensson, L. Schuler, H. (2010). Biochemistry, 49, 1056058. Karlberg, T., Markova, N., Johansson, I., Hammarstrom, M., Schutz, P., Weigelt, J. Schuler, H. (2010). J. Med. Chem. 53, 5352355. Kinoshita, T., Nakanishi, I., Warizaya, M., Iwashita, A., Kido, Y., Hattori, K. Fujii, T. (2004). FEBS Lett. 556, 436. Kummar, S., Chen, A., Parchment, R. E., Kinders, R. J., Ji, J., Tomaszewski, J. E. Doroshow, J. H. (2012). BMC Med. 10, 25. Langelier, M.-F., Planck, J. L., Roy, S. Pascal, J. M. (2012). Science, 336, 728732. Lehtio L., Collins, R., van den Berg, S., Johansson, A., Dahlgren, L. G., Hammarstrom, M., Helleday, T., Holmberg-Schiavone, L., Karlberg, T. Weigelt, J. (2008). J. Mol. Biol. 379, 13645. Lehtio L., Jemth, A. S., Collins, R., Loseva, O., Johansson, A., Markova, N., Hammarstrom, M., Flores, A., Holmberg-Schiavone, L., Weigelt, J., Helleday, T., Schuler, H. Karlberg, T. (2009). J. Med. Chem. 52, 31083111. Leung, M., Rosen, D., Fields, S., Cesano, A. Budman, D. R. (2011). Mol. Med. 17, 85462. Lindgren, A. E., Karlberg, T., Thorsell, A. G., Hesse, M., Spjut, S., Ekblad, T., Andersson, C. D., Pinto, A. F., Weigelt, J., Hottiger, M. O., Linusson, A., Elofsson, M. Schuler, H. (2013). ACS Chem. Biol. 8, 1698703. McCoy, A. J., Grosse-Kunstleve, R. W., Adams, P. D., Winn, M. D., Storoni, L. C. Study, R. J. (2007). J. Appl. Cryst. 40, 65874. Miyashiro, J., Woods, K. W., Park, C. H., Liu, X., Shi, Y., Johnson, E. F., Bouska, J. J., Olson, A. M., Luo, Y., Fry, E. H., Giranda, V. L. Penning, T. D. (2009). Bioorg. Med. Chem. Lett. 19, 4050054. Murai, J., Huang, S.-Y. N., Renaud, A., Zhang, Y., Ji, J., Takeda, S., Morris, J., Teicher, B., Doroshow, J. H. Pommier, Y. (2014). Mol. Cancer Ther. 13,.
