Product Name: IL-23p19 Antibody
Species Reactivity: Human, Mouse
Tested Applications: ELISA, WB
Applications: ELISA: (direct and indirect: 1:2,000-1:10,000). Western Blot: (1:2,000-1:10,000 using ECL; suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk; suggested incubation time is 1 hour at room temperature). Optimal conditions must be determined individually for each application.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: Recombinant mouse IL-23p19.
Host Species: Rabbit
Purification:
Physical State: Liquid
CAS NO.: 69884-00-0
Product: THS-044
Buffer: Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.
Concentration: 1 mg/ml
Storage Conditions: Stable for at least 6 months after receipt when stored at -20˚C.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Interleukin-23 Subunit p19; Interleukin-23 Subunit alpha IL-23-A
Accession NO.: Q9EQ14
Protein Ino: 81881842
Official Symbol: Il23a
Geneid: 83430
Background: IL-23p19 associates with IL-12b to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 binds to an heterodimeric receptor complex composed of IL-12RB1 and IL-23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
PubMed ID:http://aac.asm.org/content/26/3/382.abstract