Product Name: IL-23 p40 Antibody [I 1108]
Species Reactivity: Human
Tested Applications: ELISA, WB
Applications: ELISA: (direct or indirect: 1:500-1:10,000). Western blot: (1:500-1:5,000 using ECL. Suggested blocking and dilution buffer is TBST with 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at rooom temperature). Optimal conditions should be determined individually for each application.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: Recombinant human IL-23p40.
Host Species: Mouse
Purification:
Physical State: Liquid
CAS NO.: 80321-69-3
Product: Harmine
Buffer: Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.
Concentration: 1 mg/ml
Storage Conditions: Stable for at least 1 year after receipt when stored at -20˚C.
Clonality: Monoclonal
Conjugate: Unconjugated
Alternate Names: Interleukin-23 Subunit p40; IL-23 Subunit p40; Interleukin-12 Subunit beta IL-12B; Cytotoxic Lymphocyte Maturation Factor 40 kDa Subunit; CLMF p40; IL-12 Subunit p40; NK Cell Stimulatory Factor Chain 2; NKSF2
Accession NO.: NP_002178.2
Protein Ino: 24497438
Official Symbol: IL12B
Geneid: 3593
Background: IL-23p40 associates with IL-23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 binds to an heterodimeric receptor complex composed of IL-12RB1 and IL-23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. Defects in IL-23p40 are a cause of mendelian susceptibility to mycobacterial disease (MSMD). Genetic variations in IL-23p40 are a cause of susceptibility to psoriasis type 11 (PSORS11).
PubMed ID:http://aac.asm.org/content/26/3/378.abstract
