Product Name: IL-23 Antibody
Species Reactivity: Human, Mouse
Tested Applications: ELISA, ICC, IF, IHC-P, WB
Applications: IL-23 antibody can be used for the detection of IL-23 by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 10 μg/mL and immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 21 kDa
Immunogen: IL-23 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human IL-23.The immunogen is located within the last 50 amino acids of IL-23.
Host Species: Rabbit
Purification: IL-23 Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 32791-84-7
Product: thymus peptide C
Buffer: IL-23 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: IL-23 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: IL-23 Antibody: P19, SGRF, IL-23, IL-23A, IL23P19, UNQ2498/PRO5798, Interleukin-23 subunit alpha, Interleukin-23 subunit p19, IL-23 subunit alpha
Accession NO.: AAH66268
Protein Ino: 42542809
Official Symbol: IL23A
Geneid: 51561
Background: IL-23 Antibody: Like interleukin-27 (IL-27), IL-23 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the IL-12p40 subunit and a novel p19 subunit. IL-23 is secreted by activated dendritic cells, macrophages, and monocytes. Its biological activities include enhancing the proliferation of memory T cells and the production of IFN-gamma, IL-12, and TNF-α from activated T cells, and can stimulate macrophages to produce TNF-α and nitric oxide. It has also been shown to possess potent anti-tumor and anti-metastatic activity in mouse models of cancer, suggesting a potential role for IL-23 in therapeutic treatment of cancer.
PubMed ID:http://aac.asm.org/content/26/3/358.abstract
