Product Name: IL-1RL2 Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, IF, IHC-P, WB
Applications: IL-1RL2 antibody can be used for detection of IL-1RL2 by Western blot at 1 – 2 μg/ml.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: Predicted: 61 kDa Observed: 55 kDa
Immunogen: IL-1RL2 antibody was raised against a 16 amino acid peptide near the center of human IL-1RL2.The immunogen is located within amino acids 260 – 310 of IL-1RL2.
Host Species: Rabbit
Purification: IL-1RL2 antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 3819-00-9
Product: PKR-IN-2
Buffer: IL-1RL2 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: IL-1RL2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: IL-1RL2 Antibody: IL-36R, IL1RRP2, IL-1Rrp2, IL1R-rp2, Interleukin-1 receptor-like 2, IL-36 receptor, IL-36R
Accession NO.: NP_003845
Protein Ino: 28416902
Official Symbol: IL1RL2
Geneid: 8808
Background: IL-1RL2 is a member of the interleukin 1 receptor family, but it is incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity (1). Together with IL-1RAcP, it can bind members of the IL-36 cytokine family, leading to activation of the NF-kappaB pathway (2). IL-1RL2 can also bind to IL-1F10, resulting in a decreased product of Th17 cytokines in response to immunological or LPS challenge, suggesting that one potential role of IL-1RL2 may be to modulate the immune and inflammation response (3).
PubMed ID:http://aac.asm.org/content/26/3/283.abstract
