Product Name: HSPD1 Antibody
Species Reactivity: Bovine, Chicken, Chimpanzee, Dog, Human, Monkey
Tested Applications: IHC, WB
Applications: HSPD1 antibody can be used in ELISA, Western Blot, immunohistochemistry starting at 2.5 μg/mL, and immunofluorescence starting at 10 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: A portion of amino acids 350-400 of human Hsp60.
Host Species: Rabbit
Purification: Protein G Column
Physical State: Liquid
CAS NO.: 102-65-8
Product: Bromfenac (sodium hydrate)
Buffer: PBS, 0.2% gelatin, 0.05% sodium azide.
Concentration:
Storage Conditions: HSPD1 antibody can be stored short term 4 ˚C. For long term storage aliquot and store at -20 ˚C. As with all antibodies avoid freeze/thaw cycles.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: HSPD1, 60 kDa chaperonin, CPN60, Heat shock protein 65, Heat shock protein 60, HSP-60, HSP60, HuCHA60, HLD4, HSP65, p60 lymphocyte protein, SPG13, Chaperonin 60, GROEL
Accession NO.: P10809
Protein Ino: 129379
Official Symbol: HSPD1
Geneid: 3329
Background: HSP60, a 60 kDa member of Chaperonin family, is a mitochondrial protein that participates in protein folding, transport and secretion. HSP60 is a multi-functional protein whose roles include accelerating the maturation of pro-caspase 3 during apoptosis, LPS-binding, acting as a ligand for innate immune system and also binding to the surface of innate immune cells and stimulating proinflammatory reactivity. It induces the expression of IL-12 and IL-15 and also induces release of TNF-alpha, NO and IL-6. Reports suggest interaction of Hsp60 with integrin molecules during metastasis. Mutations in Hsp60 gene cause autosomal recessive spastic paraplegia 13. Hsp60 has been found to be involved in development of auto-immune disorders such as Rheumatoid arthritis, insulin-dependent diabetes mellitus, systemic sclerosis and atherosclerosis.
PubMed ID:http://aac.asm.org/content/24/4/522.abstract
