Product Name :
c-Met-IN-2
Description:
c-Met-IN-2 is a potent, selective and orally available c-Met inhibitor, with an IC50 of 0.6 nM, with antitumor activity.
CAS:
1635406-73-3
Molecular Weight:
484.49
Formula:
C24H21FN10O
Chemical Name:
2-[4-(1-1-[7-fluoro-3-(1-methyl-1H-pyrazol-4-yl)quinolin-6-yl]ethyl-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl]ethan-1-ol
Smiles :
CN1C=C(C=N1)C1C=NC2=CC(F)=C(C=C2C=1)C(C)N1N=NC2=NC=C(N=C12)C1C=NN(CCO)C=1
InChiKey:
VLBZFDFQVGAJSP-UHFFFAOYSA-N
InChi :
InChI=1S/C24H21FN10O/c1-14(19-6-15-5-16(17-9-28-33(2)12-17)8-26-21(15)7-20(19)25)35-24-23(31-32-35)27-11-22(30-24)18-10-29-34(13-18)3-4-36/h5-14,36H,3-4H2,1-2H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.Hypericin MedChemExpress
Additional information:
c-Met-IN-2 is a potent, selective and orally available c-Met inhibitor, with an IC50 of 0.6 nM, with antitumor activity.|Product information|CAS Number: 1635406-73-3|Molecular Weight: 484.49|Formula: C24H21FN10O|Chemical Name: 2-[4-(1-1-[7-fluoro-3-(1-methyl-1H-pyrazol-4-yl)quinolin-6-yl]ethyl-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl]ethan-1-ol|Smiles: CN1C=C(C=N1)C1C=NC2=CC(F)=C(C=C2C=1)C(C)N1N=NC2=NC=C(N=C12)C1C=NN(CCO)C=1|InChiKey: VLBZFDFQVGAJSP-UHFFFAOYSA-N|InChi: InChI=1S/C24H21FN10O/c1-14(19-6-15-5-16(17-9-28-33(2)12-17)8-26-21(15)7-20(19)25)35-24-23(31-32-35)27-11-22(30-24)18-10-29-34(13-18)3-4-36/h5-14,36H,3-4H2,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Zanubrutinib Btk |Shelf Life: ≥12 months if stored properly.PMID:31726890 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|c-Met-IN-2 (Compound 14) is a potent and selective c-Met inhibitor, with an IC50 of 0.6 nM. c-Met-IN-2 also shows weak activity on other kinases, with IC50s of 1075 nM (AxI), 731 nM (RON), 18364 nM (VEGFR2), 5396 nM (c-Kit), 2357 nM (PDGFRa), 17056 nM (c-Src).|In Vivo:|c-Met-IN-2 (0.1, 1, 10 mg/kg, p.o., once daily) significantly reduces the volume of tumor in mice bearing H1993 tumors, and has similar effect in SNU-5 xenograft model via oral administration at 0.3, 1 and 3 mg/kg.|Products are for research use only. Not for human use.|
