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Product Name :
OSIP-486823

Description:
OSIP-486823 is a novel microtubule-interfering agent with distinct biological effects on both protein kinase G (PKG) and microtubules.

CAS:
200803-37-8

Molecular Weight:
473.54

Formula:
C29H28FNO4

Chemical Name:
N-benzyl-2-[(1Z)-5-fluoro-2-methyl-1-[(3,4,5-trimethoxyphenyl)methylidene]-1H-inden-3-yl]acetamide

Smiles :
CC1/C(=C/C2C=C(OC)C(OC)=C(C=2)OC)/C2C=CC(F)=CC=2C=1CC(=O)NCC1C=CC=CC=1

InChiKey:
KATLSKIJHJJAEB-FMCGGJTJSA-N

InChi :
InChI=1S/C29H28FNO4/c1-18-23(12-20-13-26(33-2)29(35-4)27(14-20)34-3)22-11-10-21(30)15-25(22)24(18)16-28(32)31-17-19-8-6-5-7-9-19/h5-15H,16-17H2,1-4H3,(H,31,32)/b23-12-

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life:
≥12 months if stored properly.

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.

Additional information:
OSIP-486823 is a novel microtubule-interfering agent with distinct biological effects on both protein kinase G (PKG) and microtubules.|Product information|CAS Number: 200803-37-8|Molecular Weight: 473.54|Formula: C29H28FNO4|Chemical Name: N-benzyl-2-[(1Z)-5-fluoro-2-methyl-1-[(3,4,5-trimethoxyphenyl)methylidene]-1H-inden-3-yl]acetamide|Smiles: CC1/C(=C/C2C=C(OC)C(OC)=C(C=2)OC)/C2C=CC(F)=CC=2C=1CC(=O)NCC1C=CC=CC=1|InChiKey: KATLSKIJHJJAEB-FMCGGJTJSA-N|InChi: InChI=1S/C29H28FNO4/c1-18-23(12-20-13-26(33-2)29(35-4)27(14-20)34-3)22-11-10-21(30)15-25(22)24(18)16-28(32)31-17-19-8-6-5-7-9-19/h5-15H,16-17H2,1-4H3,(H,31,32)/b23-12-|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|OSIP486823 inhibits growth and induce apoptosis in SW480 human colon cancer cells, with IC50 of 0.SAH Epigenetic Reader Domain 1 μM.Datopotamab MedChemExpress OSIP-486823 (OSIP486823) causes depolymerization of microtubules in interphase cells, inhibit spindle formation in mitotic cells, and induce multinucleated cells.PMID:31746246 Exisulind and the potent synthetic derivative OSIP-486823 are members of a new class of drugs known as selective apoptotic antineoplastic drugs that target cyclic guanosine 3′,5′-monophosphate phosphodiesterases (cGMP-PDE). OSIP-486823 also disrupts microtubule polymerization, perturbs mitotic spindle function, and arrests cells in mitosis in human glioma cells.|Products are for research use only. Not for human use.|

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Author: Betaine hydrochloride