Product Name :
BPN-15606 besylate
Description:
BPN-15606 besylate is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC50 values of 7 nM and 17nM, respectively. BPN-15606 besylate lowers Aβ42 and Aβ40 levels in the central nervous system of rats and mice. BPN-15606 besylate has acceptable PK/PD properties, including bioavailability, half-life, and clearance.
CAS:
Molecular Weight:
576.64
Formula:
C29H29FN6O4S
Chemical Name:
benzenesulfonic acid;N-[(1S)-1-(4-fluorophenyl)ethyl]-6-[6-methoxy-5-(4-methylimidazol-1-yl)pyridin-2-yl]-4-methylpyridazin-3-amine
Smiles :
CC1C=C(N=NC=1N[C@@H](C)C1C=CC(F)=CC=1)C1=CC=C(C(=N1)OC)N1C=NC(C)=C1.OS(=O)(=O)C1C=CC=CC=1
InChiKey:
GUUNWNSGODFODV-NTISSMGPSA-N
InChi :
InChI=1S/C23H23FN6O.C6H6O3S/c1-14-11-20(28-29-22(14)26-16(3)17-5-7-18(24)8-6-17)19-9-10-21(23(27-19)31-4)30-12-15(2)25-13-30;7-10(8,9)6-4-2-1-3-5-6/h5-13,16H,1-4H3,(H,26,29);1-5H,(H,7,8,9)/t16-;/m0./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.Methotrexate Biological Activity
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
BPN-15606 besylate is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC50 values of 7 nM and 17nM, respectively. BPN-15606 besylate lowers Aβ42 and Aβ40 levels in the central nervous system of rats and mice. BPN-15606 besylate has acceptable PK/PD properties, including bioavailability, half-life, and clearance.|Product information|Molecular Weight: 576.64|Formula: C29H29FN6O4S|Chemical Name: benzenesulfonic acid;N-[(1S)-1-(4-fluorophenyl)ethyl]-6-[6-methoxy-5-(4-methylimidazol-1-yl)pyridin-2-yl]-4-methylpyridazin-3-amine|Smiles: CC1C=C(N=NC=1N[C@@H](C)C1C=CC(F)=CC=1)C1=CC=C(C(=N1)OC)N1C=NC(C)=C1.OS(=O)(=O)C1C=CC=CC=1|InChiKey: GUUNWNSGODFODV-NTISSMGPSA-N|InChi: InChI=1S/C23H23FN6O.C6H6O3S/c1-14-11-20(28-29-22(14)26-16(3)17-5-7-18(24)8-6-17)19-9-10-21(23(27-19)31-4)30-12-15(2)25-13-30;7-10(8,9)6-4-2-1-3-5-6/h5-13,16H,1-4H3,(H,26,29);1-5H,(H,7,8,9)/t16-;/m0./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.ADAM15 Protein, Human (HEK293, C-His) medchemexpress |Shelf Life: ≥12 months if stored properly.PMID:32896977 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|BPN-15606 besylate (oral administration; 10 mg/kg, 25 mg/kg and 50 mg/kg; 7 days) shows excellent dose-dependent efficacy in both plasma and brain on lowering of Aβ42 and Aβ40 levels in mice. BPN-15606 besylate (oral administration; 5 mg/kg, 25 mg/kg and 50 mg/kg; 9 days) dose-dependently reduces CSF on lowering of Aβ42 and Aβ40 levels in rats. BPN-15606 besylate (oral administration; 25 mg/kg; single dose) shows a robust effect on both brain and plasma Aβ 42 and Aβ40 levels, which begins approximately 30–60 minutes following the single dose administration and lasted for ≥24 hours in C57BL/6 mice.|Products are for research use only. Not for human use.|
