Product Name :
Apraglutide (FE 203799)
Description:
Apraglutide (FE 203799) is a potent and highly selective GLP-2 agonist with EC50s of 0.03 nM and 0.07 nM for hGLP-2 Receptor and rGLP-2 Receptor, respectively.
CAS:
1295353-98-8
Molecular Weight:
3765.19
Formula:
C172H263N43O52
Chemical Name:
Apraglutide (FE 203799)
Smiles :
C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CC1=CNC=N1)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC2=CC=CC=C12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(N)=O
InChiKey:
XMTLZMCLGUSQEW-KVZCCPQBSA-N
InChi :
InChI=1S/C172H263N43O52/c1-24-86(15)134(165(261)193-105(52-54-124(175)221)149(245)213-138(92(21)218)169(265)192-103(50-39-40-56-173)148(244)209-137(89(18)27-4)168(264)215-139(93(22)219)170(266)194-107(141(177)237)69-129(227)228)210-160(256)112(62-85(13)14)198-155(251)116(66-98-74-182-102-49-38-37-48-100(98)102)202-156(252)117(68-125(176)222)207-166(262)135(87(16)25-2)211-161(257)114(64-96-44-33-29-34-45-96)200-159(255)120(72-132(233)234)203-146(242)104(51-41-57-181-172(178)179)190-143(239)91(20)186-142(238)90(19)187-150(246)108(58-81(5)6)196-151(247)110(60-83(9)10)197-158(254)121(73-133(235)236)204-153(249)111(61-84(11)12)206-167(263)136(88(17)26-3)212-171(267)140(94(23)220)214-162(258)115(65-97-46-35-30-36-47-97)199-152(248)109(59-82(7)8)195-147(243)106(53-55-128(225)226)191-157(253)119(71-131(231)232)205-164(260)123(79-217)208-154(250)113(63-95-42-31-28-32-43-95)201-163(259)122(78-216)189-127(224)77-184-145(241)118(70-130(229)230)188-126(223)76-183-144(240)101(174)67-99-75-180-80-185-99/h28-38,42-49,74-75,80-94,101,103-123,134-140,182,216-220H,24-27,39-41,50-73,76-79,173-174H2,1-23H3,(H2,175,221)(H2,176,222)(H2,177,237)(H,180,185)(H,183,240)(H,184,241)(H,186,238)(H,187,246)(H,188,223)(H,189,224)(H,190,239)(H,191,253)(H,192,265)(H,193,261)(H,194,266)(H,195,243)(H,196,247)(H,197,254)(H,198,251)(H,199,248)(H,200,255)(H,201,259)(H,202,252)(H,203,242)(H,204,249)(H,205,260)(H,206,263)(H,207,262)(H,208,250)(H,209,244)(H,210,256)(H,211,257)(H,212,267)(H,213,245)(H,214,258)(H,215,264)(H,225,226)(H,227,228)(H,229,230)(H,231,232)(H,233,234)(H,235,236)(H4,178,179,181)/t86-,87-,88-,89-,90-,91-,92+,93+,94+,101-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,134-,135-,136-,137-,138-,139-,140-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.1-(4-Fluorophenyl)piperazine Biological Activity
Shelf Life:
≥12 months if stored properly.Tozorakimab Immunology/Inflammation
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Apraglutide (FE 203799) is a potent and highly selective GLP-2 agonist with EC50s of 0.03 nM and 0.07 nM for hGLP-2 Receptor and rGLP-2 Receptor, respectively.|Product information|CAS Number: 1295353-98-8|Molecular Weight: 3765.19|Formula: C172H263N43O52|Chemical Name: Apraglutide (FE 203799)|Smiles: C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CC1=CNC=N1)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC2=CC=CC=C12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(N)=O|InChiKey: XMTLZMCLGUSQEW-KVZCCPQBSA-N|InChi: InChI=1S/C172H263N43O52/c1-24-86(15)134(165(261)193-105(52-54-124(175)221)149(245)213-138(92(21)218)169(265)192-103(50-39-40-56-173)148(244)209-137(89(18)27-4)168(264)215-139(93(22)219)170(266)194-107(141(177)237)69-129(227)228)210-160(256)112(62-85(13)14)198-155(251)116(66-98-74-182-102-49-38-37-48-100(98)102)202-156(252)117(68-125(176)222)207-166(262)135(87(16)25-2)211-161(257)114(64-96-44-33-29-34-45-96)200-159(255)120(72-132(233)234)203-146(242)104(51-41-57-181-172(178)179)190-143(239)91(20)186-142(238)90(19)187-150(246)108(58-81(5)6)196-151(247)110(60-83(9)10)197-158(254)121(73-133(235)236)204-153(249)111(61-84(11)12)206-167(263)136(88(17)26-3)212-171(267)140(94(23)220)214-162(258)115(65-97-46-35-30-36-47-97)199-152(248)109(59-82(7)8)195-147(243)106(53-55-128(225)226)191-157(253)119(71-131(231)232)205-164(260)123(79-217)208-154(250)113(63-95-42-31-28-32-43-95)201-163(259)122(78-216)189-127(224)77-184-145(241)118(70-130(229)230)188-126(223)76-183-144(240)101(174)67-99-75-180-80-185-99/h28-38,42-49,74-75,80-94,101,103-123,134-140,182,216-220H,24-27,39-41,50-73,76-79,173-174H2,1-23H3,(H2,175,221)(H2,176,222)(H2,177,237)(H,180,185)(H,183,240)(H,184,241)(H,186,238)(H,187,246)(H,188,223)(H,189,224)(H,190,239)(H,191,253)(H,192,265)(H,193,261)(H,194,266)(H,195,243)(H,196,247)(H,197,254)(H,198,251)(H,199,248)(H,200,255)(H,201,259)(H,202,252)(H,203,242)(H,204,249)(H,205,260)(H,206,263)(H,207,262)(H,208,250)(H,209,244)(H,210,256)(H,211,257)(H,212,267)(H,213,245)(H,214,258)(H,215,264)(H,225,226)(H,227,228)(H,229,230)(H,231,232)(H,233,234)(H,235,236)(H4,178,179,181)/t86-,87-,88-,89-,90-,91-,92+,93+,94+,101-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,134-,135-,136-,137-,138-,139-,140-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Solubility (25°C).PMID:32809416 DMSO: 100 mg/mL(26.55 mM). Water: Insoluble.|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
