Product Name :
ML390
Description:
ML390 is a human DHODH inhibitor with an IC50 of 0.56 μM and induces differentiation in acute myeloid leukemia.
CAS:
2029049-79-2
Molecular Weight:
406.40
Formula:
C21H21F3N2O3
Chemical Name:
N-(1,2,3,4-tetrahydronaphthalen-1-yl)-3-[4-(trifluoromethoxy)phenyl]formamidopropanamide
Smiles :
O=C(CCNC(=O)C1C=CC(=CC=1)OC(F)(F)F)NC1CCCC2=CC=CC=C21
InChiKey:
SGNRHEDBLPGDDC-UHFFFAOYSA-N
InChi :
InChI=1S/C21H21F3N2O3/c22-21(23,24)29-16-10-8-15(9-11-16)20(28)25-13-12-19(27)26-18-7-3-5-14-4-1-2-6-17(14)18/h1-2,4,6,8-11,18H,3,5,7,12-13H2,(H,25,28)(H,26,27)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
ML390 is a human DHODH inhibitor with an IC50 of 0.56 μM and induces differentiation in acute myeloid leukemia.|Product information|CAS Number: 2029049-79-2|Molecular Weight: 406.40|Formula: C21H21F3N2O3|Chemical Name: N-(1,2,3,4-tetrahydronaphthalen-1-yl)-3-[4-(trifluoromethoxy)phenyl]formamidopropanamide|Smiles: O=C(CCNC(=O)C1C=CC(=CC=1)OC(F)(F)F)NC1CCCC2=CC=CC=C21|InChiKey: SGNRHEDBLPGDDC-UHFFFAOYSA-N|InChi: InChI=1S/C21H21F3N2O3/c22-21(23,24)29-16-10-8-15(9-11-16)20(28)25-13-12-19(27)26-18-7-3-5-14-4-1-2-6-17(14)18/h1-2,4,6,8-11,18H,3,5,7,12-13H2,(H,25,28)(H,26,27)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO: 27 mg/mL (66.44 mM)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Mifepristone Description |Shelf Life: ≥12 months if stored properly.Ephrin-B2/EFNB2 Protein, Human (HEK293, His, Fc) Data Sheet |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33342292 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|ML390 was active with an ED50 (effective concentration triggering 50% of its maximal differentiation activity) of 2 μM in murine and human AML cell lines, offering insight into the mechanism of overcoming differentiation arrest. DHODH inhibitors demonstrated effective at prolonging survival in animal models of leukemia.|References:|Sykes DB et al. Discovering Small Molecules that Overcome Differentiation Arrest in Acute Myeloid Leukemia. National Center for Biotechnology Information (US); 2010-2013 Dec 15.David B Sykes, et al. Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia. Cell. 2016 Sep 22;167(1):171-186.e15.Timothy A Lewis, et al. Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia. ACS Med Chem Lett. 2016 Sep 28;7(12):1112-1117.Products are for research use only. Not for human use.|
