Product Name :
Flavokawain A
Description:
Flavokawain A, a proming anticarcinogenic agent, is a chalcone from kava extract with anti-tumor activity. Flavokawain A induces cell apoptosis by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway. Flavokawain A has the potential for the study of bladder cancer.
CAS:
3420-72-2
Molecular Weight:
314.33
Formula:
C18H18O5
Chemical Name:
(2E)-1-(2-hydroxy-4, 6-dimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
Smiles :
COC1C=C(O)C(C(=O)/C=C/C2C=CC(=CC=2)OC)=C(C=1)OC
InChiKey:
CGIBCVBDFUTMPT-RMKNXTFCSA-N
InChi :
InChI=1S/C18H18O5/c1-21-13-7-4-12(5-8-13)6-9-15(19)18-16(20)10-14(22-2)11-17(18)23-3/h4-11,20H,1-3H3/b9-6+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Flavokawain A, a proming anticarcinogenic agent, is a chalcone from kava extract with anti-tumor activity.Prodigiosin web Flavokawain A induces cell apoptosis by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway. Flavokawain A has the potential for the study of bladder cancer.|Product information|CAS Number: 3420-72-2|Molecular Weight: 314.33|Formula: C18H18O5|Chemical Name: (2E)-1-(2-hydroxy-4, 6-dimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one|Smiles: COC1C=C(O)C(C(=O)/C=C/C2C=CC(=CC=2)OC)=C(C=1)OC|InChiKey: CGIBCVBDFUTMPT-RMKNXTFCSA-N|InChi: InChI=1S/C18H18O5/c1-21-13-7-4-12(5-8-13)6-9-15(19)18-16(20)10-14(22-2)11-17(18)23-3/h4-11,20H,1-3H3/b9-6+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (318.14 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Vipivotide tetraxetan Autophagy |Shelf Life: ≥360 days if stored properly.PMID:32657562 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Curzerene (0-100 µM; 24-72 hours) indicates that cell inhibition increases in a dose- and time-dependent manner, IC50 to SPC A1 cells at 24, 48, and 72 h was 403.8 μM, 154.8 µM, and 47.01 µM, respectively. Curzerene (0-100 µM; 48 hours) exhibits a higher percentage of apoptotic and necrotic cells than that of the control group in SPC-A1cells. Curzerene(0-100 µM; 48 hours) indicates that the percentage of cells arrested in the G2/M phase increased from 9.26% in the control group cells to 17.57% in the cells treated with the highest dose. Curzerene (6.25-100 µM; 48 hours) decreases the mRNA expression of GSTA1 in SPC A1 cells. Curzerene (6.25-100 µM; 48 hours) decreases the protein expression of GSTA1 in SPC A1 cells.|References:|Wang Y, et al. Cytotoxic and Antitumor Effects of Curzerene from Curcuma longa. Planta Med. 2017 Jan;83(1-02):23-29.Products are for research use only. Not for human use.|
