Product Name :
[Ser25] Protein Kinase C (19-31)
Description:
Protein Kinase C (19-31), (C67H118N26O17), a peptide with the sequence H-ARG-PHE-ALA-ARG-LYS-GLY-SER-LEU-ARG-GLN-LYS-ASN-VAL-OH, MW= 1559.82. this peptide derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31) with a serine at position 25 replacing the wild-type alanine, it was used as protein kinase C substrate peptide for testing the protein kinase C activity. Protein kinase C also known as PKC, is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins. PKCa has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca2+ handling in myocytes.
CAS:
136795-05-6
Molecular Weight:
1559.82
Formula:
C67H118N26O17
Chemical Name:
2-[2-(6-amino-2-{2-[2-(2-{2-[2-(6-amino-2-{2-[2-(2-{2-amino-5-[(diaminomethylidene)amino]pentanamido}-3-phenylpropanamido)propanamido]-5-[(diaminomethylidene)amino]pentanamido}hexanamido)acetamido]-3-hydroxypropanamido}-4-methylpentanamido)-5-[(diaminomethylidene)amino]pentanamido]-4-carbamoylbutanamido}hexanamido)-3-carbamoylpropanamido]-3-methylbutanoic acid
Smiles :
CC(NC(=O)C(CC1C=CC=CC=1)NC(=O)C(N)CCCN=C(N)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCCN)C(=O)NCC(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCC(N)=O)C(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NC(C(C)C)C(O)=O
InChiKey:
JLTBKSGYPRXXGI-UHFFFAOYSA-N
InChi :
InChI=1S/C67H118N26O17/c1-35(2)30-45(61(106)88-43(22-15-29-81-67(77)78)57(102)89-44(23-24-49(71)95)59(104)87-41(20-10-12-26-69)58(103)92-47(32-50(72)96)62(107)93-52(36(3)4)64(109)110)91-63(108)48(34-94)84-51(97)33-82-55(100)40(19-9-11-25-68)86-56(101)42(21-14-28-80-66(75)76)85-53(98)37(5)83-60(105)46(31-38-16-7-6-8-17-38)90-54(99)39(70)18-13-27-79-65(73)74/h6-8,16-17,35-37,39-48,52,94H,9-15,18-34,68-70H2,1-5H3,(H2,71,95)(H2,72,96)(H,82,100)(H,83,105)(H,84,97)(H,85,98)(H,86,101)(H,87,104)(H,88,106)(H,89,102)(H,90,99)(H,91,108)(H,92,103)(H,93,107)(H,109,110)(H4,73,74,79)(H4,75,76,80)(H4,77,78,81)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{5-Ethynyl-2′-deoxyuridine} site|{5-Ethynyl-2′-deoxyuridine} PROTAC Linkers|{5-Ethynyl-2′-deoxyuridine} Immunology/Inflammation|{5-Ethynyl-2′-deoxyuridine} Biological Activity|{5-Ethynyl-2′-deoxyuridine} References|{5-Ethynyl-2′-deoxyuridine} custom synthesis}
Additional information:
Protein Kinase C (19-31), (C67H118N26O17), a peptide with the sequence H-ARG-PHE-ALA-ARG-LYS-GLY-SER-LEU-ARG-GLN-LYS-ASN-VAL-OH, MW= 1559.{{Ipronidazole} medchemexpress|{Ipronidazole} Parasite|{Ipronidazole} Immunology/Inflammation|{Ipronidazole} Protocol|{Ipronidazole} Purity|{Ipronidazole} supplier} 82.PMID:25105126 this peptide derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31) with a serine at position 25 replacing the wild-type alanine, it was used as protein kinase C substrate peptide for testing the protein kinase C activity. Protein kinase C also known as PKC, is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins. PKCa has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca2+ handling in myocytes.|Product information|CAS Number: 136795-05-6|Molecular Weight: 1559.82|Formula: C67H118N26O17|Chemical Name: 2-[2-(6-amino-2-{2-[2-(2-{2-[2-(6-amino-2-{2-[2-(2-{2-amino-5-[(diaminomethylidene)amino]pentanamido}-3-phenylpropanamido)propanamido]-5-[(diaminomethylidene)amino]pentanamido}hexanamido)acetamido]-3-hydroxypropanamido}-4-methylpentanamido)-5-[(diaminomethylidene)amino]pentanamido]-4-carbamoylbutanamido}hexanamido)-3-carbamoylpropanamido]-3-methylbutanoic acid|Smiles: CC(NC(=O)C(CC1C=CC=CC=1)NC(=O)C(N)CCCN=C(N)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCCN)C(=O)NCC(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCC(N)=O)C(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NC(C(C)C)C(O)=O|InChiKey: JLTBKSGYPRXXGI-UHFFFAOYSA-N|InChi: InChI=1S/C67H118N26O17/c1-35(2)30-45(61(106)88-43(22-15-29-81-67(77)78)57(102)89-44(23-24-49(71)95)59(104)87-41(20-10-12-26-69)58(103)92-47(32-50(72)96)62(107)93-52(36(3)4)64(109)110)91-63(108)48(34-94)84-51(97)33-82-55(100)40(19-9-11-25-68)86-56(101)42(21-14-28-80-66(75)76)85-53(98)37(5)83-60(105)46(31-38-16-7-6-8-17-38)90-54(99)39(70)18-13-27-79-65(73)74/h6-8,16-17,35-37,39-48,52,94H,9-15,18-34,68-70H2,1-5H3,(H2,71,95)(H2,72,96)(H,82,100)(H,83,105)(H,84,97)(H,85,98)(H,86,101)(H,87,104)(H,88,106)(H,89,102)(H,90,99)(H,91,108)(H,92,103)(H,93,107)(H,109,110)(H4,73,74,79)(H4,75,76,80)(H4,77,78,81)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
