anti-girk2 rabbit mab

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Recombinant Rabbit Monoclonal Anti-GIRK2 Rabbit mAb Clone Number: JRMR-10433-48 Host: Rabbit Clonality: Recombinant Monoclonal Applications： WB Reactivity: Mouse Synonyms: KCNJ6, inwardly rectifying subfamily J member 6 Product Size 100 μl ADD TO CART BUY NOW Quantity Shipping: Ambient temperature Order online or send purchase order to [email protected] FAQ Technical Support Protocols General Information Product Usage Information Properties Target Information Images Recommended Products References BUY NOW General Information Isotype IgG Conjugate Unconjugated Synonyms KCNJ6, inwardly rectifying subfamily J member 6 UniProt ID P48542 Immunogen MW (kDa) Specificity Product Usage Information Applications Dilution Recommended Species WB 1:2000-1:5000 Mouse Properties Purity Protein A purified Constituents PBS, Glycerol, BSA Storage Store at -20°C. Avoid freeze/thaw cycles. Stability Stable for 12 months from date of receipt/reconstitution. Target Information Background GIRK2 is a member of G protein-coupled inwardly rectifying potassium channel family proteins (GIRKs). GIRK family proteins allow potassium to flow into the cell and therefore control cellular excitability in the central nervous system, heart, and pancreas. Activation of most GIRK channels requires heterologous subunit assembly and the presence of ATP. GIRK2 is abundantly expressed in the brain, where it is involved in pain perception. It is also required for peripheral opioid-mediated analgesia. Additionally GIRK2 localizes to pancreatic β cells and regulates insulin secretion. Mutations in the KCNJ6 gene encoding GIRK2 are associated with Keppen-Lubinsky Syndrome, a rare disease characterized by severe developmental delay, facial dysmorphism, and intellectual disability. Cellular location Cell membrane Images WB Blocking buffer: 5% NFDM/TBSTPrimary Ab dilution: 1:5000Primary Ab incubation condition: 2 hours at room temperature Secondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)Lysate: 1: Mouse liver (Negative control) ,2: Mouse brain Protein loading amount: 20 μgExposure time: 60 secondsPredicted band size: 48 kDa Observed band size: 40, 48 kDa :
Recombinant Rabbit Monoclonal Anti-GIRK2 Rabbit mAb Clone Number: JRMR-10433-48 Host: Rabbit Clonality: Recombinant Monoclonal Applications： WB Reactivity: Mouse Synonyms: KCNJ6, inwardly rectifying subfamily J member 6 Product Size 100 μl ADD TO CART BUY NOW Quantity Shipping: Ambient temperature Order online or send purchase order to [email protected] FAQ Technical Support Protocols General Information Product Usage Information Properties Target Information Images Recommended Products References BUY NOW General Information Isotype IgG Conjugate Unconjugated Synonyms KCNJ6, inwardly rectifying subfamily J member 6 UniProt ID P48542 Immunogen MW (kDa) Specificity Product Usage Information Applications Dilution Recommended Species WB 1:2000-1:5000 Mouse Properties Purity Protein A purified Constituents PBS, Glycerol, BSA Storage Store at -20°C. Avoid freeze/thaw cycles. Stability Stable for 12 months from date of receipt/reconstitution. Target Information Background GIRK2 is a member of G protein-coupled inwardly rectifying potassium channel family proteins (GIRKs). GIRK family proteins allow potassium to flow into the cell and therefore control cellular excitability in the central nervous system, heart, and pancreas. Activation of most GIRK channels requires heterologous subunit assembly and the presence of ATP. GIRK2 is abundantly expressed in the brain, where it is involved in pain perception. It is also required for peripheral opioid-mediated analgesia. Additionally GIRK2 localizes to pancreatic β cells and regulates insulin secretion. Mutations in the KCNJ6 gene encoding GIRK2 are associated with Keppen-Lubinsky Syndrome, a rare disease characterized by severe developmental delay, facial dysmorphism, and intellectual disability. Cellular location Cell membrane Images WB Blocking buffer: 5% NFDM/TBSTPrimary Ab dilution: 1:5000Primary Ab incubation condition: 2 hours at room temperature Secondary Ab: Goat Anti-Rabbit IgG H&L pAb (HRP Conjugate)Lysate: 1: Mouse liver (Negative control) ,2: Mouse brain Protein loading amount: 20 μgExposure time: 60 secondsPredicted band size: 48 kDa Observed band size: 40, 48 kDa