Product Name :
Tenovin-1
Description:
Tenovin-1 is a p53 activator that protects against MDM2-mediated p53 degradation.
CAS:
380315-80-0
Molecular Weight:
369.48
Formula:
C20H23N3O2S
Chemical Name:
N -[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1, 1-dimethylethyl)benzamide
Smiles :
CC(=O)NC1C=CC(=CC=1)NC(=S)NC(=O)C1C=CC(=CC=1)C(C)(C)C
InChiKey:
WOWJIWFCOPZFGV-UHFFFAOYSA-N
InChi :
InChI=1S/C20H23N3O2S/c1-13(24)21-16-9-11-17(12-10-16)22-19(26)23-18(25)14-5-7-15(8-6-14)20(2,3)4/h5-12H,1-4H3,(H,21,24)(H2,22,23,25,26)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Tenovin-1 is a p53 activator that protects against MDM2-mediated p53 degradation.|Product information|CAS Number: 380315-80-0|Molecular Weight: 369.48|Formula: C20H23N3O2S|Chemical Name: N -[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1, 1-dimethylethyl)benzamide|Smiles: CC(=O)NC1C=CC(=CC=1)NC(=S)NC(=O)C1C=CC(=CC=1)C(C)(C)C|InChiKey: WOWJIWFCOPZFGV-UHFFFAOYSA-N|InChi: InChI=1S/C20H23N3O2S/c1-13(24)21-16-9-11-17(12-10-16)22-19(26)23-18(25)14-5-7-15(8-6-14)20(2,3)4/h5-12H,1-4H3,(H,21,24)(H2,22,23,25,26)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO: 74 mg/mL(200.{{Cefoperazone} site|{Cefoperazone} Bacterial|{Cefoperazone} Technical Information|{Cefoperazone} In stock|{Cefoperazone} manufacturer|{Cefoperazone} Autophagy} 28 mM).{{Carotuximab} web|{Carotuximab} TGF-beta/Smad|{Carotuximab} Activator|{Carotuximab} Purity & Documentation|{Carotuximab} In Vitro|{Carotuximab} custom synthesis} Water: Insoluble.PMID:24624203 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Tenovin-1 is a p53 activator and elevates the amount of p53 protein within 2 hr of treatment. Tenovin-1 treatment does not alter p53 mRNA levels. Tenovin-1 (10μM) protects p53 from mdm2-mediated degradation with little effect on p53 synthesis. Tenovin-1 represses cell growth, and induces apoptosis in a panel of tumor cells expressing p53. Tenovin-1 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2, two important members of the sirtuin family.|In Vivo:|Initial in vivo experiments indicated that tenovin-1 impairs the growth of BL2-derived tumor xenografts.|References:|Marcus J G W Ladds, et al. J Biol Chem . 2020 Sep 8;jbc.RA119.012056.Lain S, et al. Cancer Cell, 2008, 13(5), 454-463.Products are for research use only. Not for human use.|
