Product Name :
BAY-1251152 racemate
Description:
BAY-1251152 racemate, also known as (±)-BAY-1251152, is a racemic mixture of BAY-1251152. BAY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor. BAY1251152 binds to and blocks the phosphorylation and kinase activity of CDK9, thereby preventing PTEFb-mediated activation of RNA Pol II and leading to the inhibition of gene transcription of various anti-apoptotic proteins. This may cause cell cycle arrest and induce apoptosis, which may lead to a reduction in tumor cell proliferation.
CAS:
1610358-53-6
Molecular Weight:
404.43
Formula:
C19H18F2N4O2S
Chemical Name:
2-Pyridinamine, 5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-[4-[(S-methylsulfonimidoyl)methyl]-2-pyridinyl]-
Smiles :
COC1=CC(F)=CC=C1C1=CC(NC2=CC(CS(C)(=N)=O)=CC=N2)=NC=C1F
InChiKey:
YZCUMZWULWOUMD-UHFFFAOYSA-N
InChi :
InChI=1S/C19H18F2N4O2S/c1-27-17-8-13(20)3-4-14(17)15-9-19(24-10-16(15)21)25-18-7-12(5-6-23-18)11-28(2,22)26/h3-10,22H,11H2,1-2H3,(H,23,24,25)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical.{{L-NAME} web|{L-NAME} Inhibitor|{L-NAME} Epigenetics|{L-NAME} Technical Information|{L-NAME} References|{L-NAME} supplier} This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.{{Tozorakimab} web|{Tozorakimab} Interleukin Related|{Tozorakimab} Activator|{Tozorakimab} Technical Information|{Tozorakimab} Purity|{Tozorakimab} supplier}
Storage Condition :
Dry, dark and at 0-4oC for short term (days to weeks) or -20oC for long term (months to years).PMID:24507727
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0-4oC for short term (days to weeks), or -20oC for long term (months).
Additional information:
BAY-1251152 racemate, also known as (±)-BAY-1251152, is a racemic mixture of BAY-1251152. BAY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor. BAY1251152 binds to and blocks the phosphorylation and kinase activity of CDK9, thereby preventing PTEFb-mediated activation of RNA Pol II and leading to the inhibition of gene transcription of various anti-apoptotic proteins. This may cause cell cycle arrest and induce apoptosis, which may lead to a reduction in tumor cell proliferation.|Product information|CAS Number: 1610358-53-6|Molecular Weight: 404.43|Formula: C19H18F2N4O2S|Synonym:|BAY-1251152 racemate|BAY1251152|BAY 1251152|(±)-BAY-1251152|((2-((5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)amino)pyridin-4-yl)methyl)(imino)(methyl)-l6-sulfanone|Related CAS Number:|1610358-56-9 ((+)BAY-1251152)|1610358-59-2 ((-)BAY-1251152)|1610368-59-6 ((R)BAY-1251152 HCl)|1610408-96-2 ((R)BAY-1251152)|1610408-97-3 ((S)(R)BAY-1251152)|1610368-60-9 ((S)BAY-1251152 HCl)|Chemical Name: 2-Pyridinamine, 5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-[4-[(S-methylsulfonimidoyl)methyl]-2-pyridinyl]-|Smiles: COC1=CC(F)=CC=C1C1=CC(NC2=CC(CS(C)(=N)=O)=CC=N2)=NC=C1F|InChiKey: YZCUMZWULWOUMD-UHFFFAOYSA-N|InChi: InChI=1S/C19H18F2N4O2S/c1-27-17-8-13(20)3-4-14(17)15-9-19(24-10-16(15)21)25-18-7-12(5-6-23-18)11-28(2,22)26/h3-10,22H,11H2,1-2H3,(H,23,24,25)|Technical Data|Appearance: Solid powder|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO: 50mg/mL|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.|Storage Condition: Dry, dark and at 0-4oC for short term (days to weeks) or -20oC for long term (months to years).|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0-4oC for short term (days to weeks), or -20oC for long term (months).|Drug Formulation: This drug may be formulated in DMSO|HS Tariff Code: 2934.99.9001|References:|Luecking, et al. Identification of potent and highly selective PTEFb inhibitor BAY 1251152 for the treatment of cancer: from p.o. to i.v. application via scaffold hops [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 984. doi:10.1158/1538-7445.AM2017-984.Products are for research use only. Not for human use.|
