Product Name :
RJR-2403 (oxalate)
Description:
Metanicotine, also known as RJR-2403 and TC-2403, is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype. Metanicotine has high affinity to rat brain cortex (Ki = 26 +/- 3 nM). Metanicotine is comparable to nicotine in activating rat thalamic synaptosomes (EC50 = 732 +/- 155 nM and Emax = 91 +/- 8% for RJR-2403; EC50 = 591 +/- 120 nM and Emax = 100 +/- 25% for nicotine) . Chronic administration of RJR-2403 in combination with low-dose of 17beta-estradiol corrects passive avoidance learning in ovariectomized rats. RJR-2403 compensates the impairment of eyeblink conditioning produced by the noncompetitive NMDA-receptor antagonist MK-801.
CAS:
220662-95-3
Molecular Weight:
252.27
Formula:
C12H16N2O4
Chemical Name:
methyl[(3E)-4-(pyridin-3-yl)but-3-en-1-yl]amine; oxalic acid
Smiles :
CNCC/C=C/C1=CN=CC=C1.OC(=O)C(O)=O
InChiKey:
WTIZFOAIQXMQHC-DPZBITMOSA-N
InChi :
InChI=1S/C10H14N2.C2H2O4/c1-11-7-3-2-5-10-6-4-8-12-9-10;3-1(4)2(5)6/h2,4-6,8-9,11H,3,7H2,1H3;(H,3,4)(H,5,6)/b5-2+;
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{SS-208} MedChemExpress|{SS-208} Epigenetics|{SS-208} Purity & Documentation|{SS-208} Purity|{SS-208} manufacturer|{SS-208} Cancer}
Shelf Life:
≥360 days if stored properly.{{Olorofim} medchemexpress|{Olorofim} Anti-infection|{Olorofim} Purity & Documentation|{Olorofim} Purity|{Olorofim} supplier|{Olorofim} Autophagy}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23935843
Additional information:
Metanicotine, also known as RJR-2403 and TC-2403, is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype. Metanicotine has high affinity to rat brain cortex (Ki = 26 +/- 3 nM). Metanicotine is comparable to nicotine in activating rat thalamic synaptosomes (EC50 = 732 +/- 155 nM and Emax = 91 +/- 8% for RJR-2403; EC50 = 591 +/- 120 nM and Emax = 100 +/- 25% for nicotine) . Chronic administration of RJR-2403 in combination with low-dose of 17beta-estradiol corrects passive avoidance learning in ovariectomized rats. RJR-2403 compensates the impairment of eyeblink conditioning produced by the noncompetitive NMDA-receptor antagonist MK-801.|Product information|CAS Number: 220662-95-3|Molecular Weight: 252.27|Formula: C12H16N2O4|Chemical Name: methyl[(3E)-4-(pyridin-3-yl)but-3-en-1-yl]amine; oxalic acid|Smiles: CNCC/C=C/C1=CN=CC=C1.OC(=O)C(O)=O|InChiKey: WTIZFOAIQXMQHC-DPZBITMOSA-N|InChi: InChI=1S/C10H14N2.C2H2O4/c1-11-7-3-2-5-10-6-4-8-12-9-10;3-1(4)2(5)6/h2,4-6,8-9,11H,3,7H2,1H3;(H,3,4)(H,5,6)/b5-2+;|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
